{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:57:56Z","timestamp":1792303076378,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal jaundice and phototherapy have been associated with the development of allergic diseases. It has been suggested, however, that effect estimates of the associations might be smaller than expected. We sought to update the evidence of their associations including recently published large longitudinal studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sought published and unpublished observational studies through the major databases. We used a random\u2010effect meta\u2010analysis model weighted by the inverse variance estimate, the Quality in Prognosis Studies tool to assess the methodological quality for each study, and the Grading of Recommendations, Assessment, Development, and Evaluation approach to assess the certainty of evidence (COE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen studies were enrolled in the qualitative syntheses, and fourteen studies were synthesized in the meta\u2010analyses. Neonatal jaundice was associated with a higher risk of childhood\u2010onset asthma (odds ratio [OR], 1.46; 95% confidence interval [95% CI], 1.39\u20101.53; COE, moderate), atopic dermatitis (AD; OR, 1.30; 95% CI, 1.07\u20101.57; COE, moderate), and allergic rhinitis (AR; OR, 3.01; 95% CI, 0.8810.30; COE, low). Neonatal phototherapy was also associated with a higher risk of childhood\u2010onset asthma (OR, 1.24; 95% CI, 1.11\u20101.38; COE, moderate), AD (OR, 1.31; 95% CI, 1.24\u20101.39; COE, moderate), and AR (OR, 1.38; 95% CI, 0.93\u20102.04; COE, very low). There were no studies that reported effect estimates of the associations between childhood\u2010onset food allergies and neonatal jaundice and phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neonatal jaundice and phototherapy were probably a prognostic factor of childhood\u2010onset allergic diseases; however, the associations were likely to be smaller than previously estimated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13456","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T19:02:02Z","timestamp":1611255722000},"page":"690-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Neonatal jaundice, phototherapy and childhood allergic diseases: An updated systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-0037","authenticated-orcid":false,"given":"Yasutaka","family":"Kuniyoshi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tsugaruhoken Medical COOP Kensei Hospital Hirosaki Japan"},{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG) Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-5589","authenticated-orcid":false,"given":"Yasushi","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG) Osaka Japan"},{"name":"Department of Nephrology and Dialysis Kyoritsu Hospital Kawanishi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2539-1031","authenticated-orcid":false,"given":"Masahiro","family":"Banno","sequence":"additional","affiliation":[{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG) Osaka Japan"},{"name":"Department of Psychiatry Seichiryo Hospital Nagoya Japan"},{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1218-4225","authenticated-orcid":false,"given":"Shunsuke","family":"Taito","sequence":"additional","affiliation":[{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG) Osaka Japan"},{"name":"Division of Rehabilitation Department of Clinical Practice and Support Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-3427","authenticated-orcid":false,"given":"Takashi","family":"Ariie","sequence":"additional","affiliation":[{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG) Osaka Japan"},{"name":"Department of Physical Therapy School of Health Sciences at Fukuoka International University of Health and Welfare Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2012.03.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1865-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.12.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/11873_17"},{"key":"e_1_2_9_7_1","first-page":"679","article-title":"Neonatal jaundice. An update for family physicians","volume":"28","author":"Kumar RK","year":"1999","journal-title":"Aust Fam Physician"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.47102\/annals-acadmedsg.V38N3p217","article-title":"Differential risk for early breastfeeding jaundice in a multi\u2010ethnic Asian cohort","volume":"38","author":"Huang A","year":"2009","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12281"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13369"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2018.03.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489389"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0662"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12560"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.89"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.015"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200603210-00010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00009"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_9_22_1","unstructured":"HigginsJP ThomasJ ChandlerJ editors.Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019).2019. Available fromwww.training.cochrane.org\/handbook"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0329"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.12.023"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h870"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.12.007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.12.015"},{"issue":"212","key":"e_1_2_9_28_1","article-title":"Neonatal Jaundice: The other side of the coin in the development of allergy","volume":"1","author":"Safar H","year":"2019","journal-title":"Am J Perinatol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2018.39.4122"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt248"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3874"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01345.x"},{"key":"e_1_2_9_33_1","first-page":"97","article-title":"The relation between neonatal phototherapy and childhood asthma","volume":"25","author":"Heidarzadeh Arani M","year":"2011","journal-title":"Indian J Allergy Asthma Immunol"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02464.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01038.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.59566\/IJBS.2010.6008","article-title":"Is there a role of early neonatal events in susceptibility to allergy?","volume":"6","author":"Gloria\u2010Bottini F","year":"2010","journal-title":"Int J Biomed Sci"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00746.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00518.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1454-1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088574"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/1110-2098.132735"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000171216"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243311"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.06.013"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02799.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.104575"},{"key":"e_1_2_9_47_1","first-page":"0319","article-title":"Neonatal jaundice: phototherapy. BMJ","volume":"2015","author":"Woodgate P","year":"2015","journal-title":"Clin Evid"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243311"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.06.013"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.10.037"},{"key":"e_1_2_9_51_1","first-page":"707","article-title":"The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma","volume":"5","author":"Bantz SK","year":"2014","journal-title":"J Clin Cell Immunol"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00391.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.010"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70370-2"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta14080"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13456","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:11:45Z","timestamp":1697649105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13456"}},"subtitle":[],"editor":[{"given":"Rachel","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,20]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/pai.13456"],"URL":"https:\/\/doi.org\/10.1111\/pai.13456","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,20]]},"assertion":[{"value":"2020-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}