{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:13Z","timestamp":1772160853206,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Selective IgM deficiency (sIgMD) is classified under primary immunodeficiencies (PID). This study aimed to define the clinical and immunologic features of sIgMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient and Methods<\/jats:title>\n                    <jats:p>We assessed a retrospective medical record of patients who fulfilled the diagnostic criteria for sIgMD in a pediatric immunology department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 55 patients with sIgMD. Out of 55 patients, 13 (23.6%) patients, diagnosed with a well\u2010defined PID disease, and nine, evaluated as transient hypogammaglobulinemia, were excluded in the follow\u2010up. The ratio of the sIgMD was %0.12 in the outpatient clinic of pediatric immunology (33\/27,000). Out of 33 patients, eight (24,2%) were asymptomatic during the follow\u2010up period. Fifteen (45.4%) patients presented with upper\/lower respiratory and skin infections. Six patients (18%) had chromosomal anomaly, or syndrome (trisomy 21, 22q11.2 deletion 1p deletion, CHARGE syndrome, and Cohen syndrome). Six (18%) had autoimmune\/inflammatory diseases, such as Behcet's disease, immune thrombocytopenic purpura, Crohn's disease, Guillain\u2010Barre syndrome, and diabetes mellitus. Five (15%) had allergic disorders. Three patients (9%) developed malignancy. The PID diagnoses were combined immunodeficiency, common variable immunodeficiency, chronic granulomatous disease, adenosine deaminase deficiency, and congenital neutropenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Genetic disorders, autoimmune\/inflammatory, and allergic diseases may accompany sIgMD. Approximately 25% of the patients were asymptomatic in our series. Patients had increased malignancy risk. We diagnosed about 25% of the patients having low IgM with a specific PID in the follow\u2010up period. Thus, patients with sIgMD should be followed up regularly in immunology clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13497","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T18:06:15Z","timestamp":1615485975000},"page":"1327-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Selective IgM deficiency: Follow\u2010up and outcome"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-6407","authenticated-orcid":false,"given":"Canan","family":"Caka","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hacettepe University Medical School Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Cimen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hacettepe University Medical School Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Kahyao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hacettepe University Medical School Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lhan","family":"Tezcan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology Department of Pediatrics Hacettepe University Medical School Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-4627","authenticated-orcid":false,"given":"Deniz","family":"Cagdas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology Department of Pediatrics Hacettepe University Medical School Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/624850"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02984"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"547","article-title":"IgM deficiency: clinical spectrum and immunologic assessment","volume":"62","author":"Guill MF","year":"1989","journal-title":"Ann Allergy"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5579.583"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.02.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091\u20106749(75)80006\u20106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010013\u20108375\u2010x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12396"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01056"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010017\u20100420\u20108"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.29.9.773"},{"key":"e_1_2_9_13_1","volume-title":"Transient hypogammaglobulinemia of infancy. StatPearls","author":"Justiz Vaillant AA","year":"2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13345"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(69)92044\u20103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1081\u20101206(10)60962\u20103"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000222682"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210875"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20639"},{"issue":"6","key":"e_1_2_9_20_1","first-page":"55","article-title":"Comprehensive clinical and immunological features of 62 adult patients with selective primary IgM deficiency","volume":"8","author":"Lucuab\u2010Fegurgur DL","year":"2019","journal-title":"Am J Clin Exp Immunol"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010017\u20100465\u20108"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010019\u201000641\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010020\u201000761\u20102"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T03:36:56Z","timestamp":1692934616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13497"}},"subtitle":[],"editor":[{"given":"Marina","family":"Atanaskovic\u2010Markovic","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/pai.13497"],"URL":"https:\/\/doi.org\/10.1111\/pai.13497","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.13497\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13497\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13497\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13497\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13497\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13497\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13497\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13497\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"assertion":[{"value":"2020-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}