{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:32:31Z","timestamp":1790814751087,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma is a heterogeneous disease in which the interaction between genetic and environmental factors plays a major role. The significance of blood eosinophil is unclear. The aim of the study was to determine the significance of blood eosinophil count in moderate\u2010to\u2010severe asthmatic children of preschool age and school age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cross\u2010sectional study performed from 2011 to 2015 including children from the severe asthma molecular phenotype (SAMP) cohort at Trousseau Hospital (Paris, France). We included children with severe and moderate asthma, or severe and moderate recurrent wheeze, aged from 1 to 15\u00a0years at the time of exploration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed data from 402 children: 248 of preschool age and 154 of school age. Blood eosinophil count third quartile thresholds were 322 and 600\u00a0cells\/\u03bcL for the preschool\u2010 and school\u2010age groups, respectively. In multivariate analysis, a blood eosinophil count over this threshold was associated with elevated total IgE (OR\u00a0=\u00a05.33,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01), multiple hospitalizations for asthma attacks (OR\u00a0=\u00a04.96,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03), and a maternal history of asthma (OR\u00a0=\u00a04.91,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01) in preschool children; and with staphylococcal toxin\u2013specific IgE (OR\u00a0=\u00a02.75,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03) in children of school age. Random forest analysis reinforced these results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High blood eosinophil count is linked to both atopic features and control of asthma with different parameters associated with these features depending on age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13507","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T08:21:46Z","timestamp":1616574106000},"page":"1217-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants of blood eosinophilia in moderate and severe asthmatic patients during childhood: Evidence from the severe asthma molecular phenotype (SAMP) cohort"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-2429","authenticated-orcid":false,"given":"Jocelyne","family":"Just","sequence":"first","affiliation":[{"name":"Department of Allergology H\u00f4pital d\u2019Enfants Armand Trousseau APHP Paris France"},{"name":"Sorbonne Universit\u00e9s Paris France"},{"name":"Equipe EPAR Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique UMR_S1136 INSERM Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Saf","sequence":"additional","affiliation":[{"name":"Department of Allergology H\u00f4pital d\u2019Enfants Armand Trousseau APHP Paris France"},{"name":"Equipe EPAR Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique UMR_S1136 INSERM Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamazoust","family":"Guiddir","sequence":"additional","affiliation":[{"name":"Department of Allergology H\u00f4pital d\u2019Enfants Armand Trousseau APHP Paris France"},{"name":"Equipe EPAR Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique UMR_S1136 INSERM Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Cottel","sequence":"additional","affiliation":[{"name":"Department of Allergology H\u00f4pital d\u2019Enfants Armand Trousseau APHP Paris France"},{"name":"Equipe EPAR Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique UMR_S1136 INSERM Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-7999","authenticated-orcid":false,"given":"Flore","family":"Amat","sequence":"additional","affiliation":[{"name":"Department of Allergology H\u00f4pital d\u2019Enfants Armand Trousseau APHP Paris France"},{"name":"Sorbonne Universit\u00e9s Paris France"},{"name":"Equipe EPAR Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique UMR_S1136 INSERM Paris France"},{"name":"Laboratory of Biochemistry and Molecular Biology\u2010 Laboratoire de Biochimie et Biologie Mol\u00e9culaire H\u00f4pital d\u2019Enfants Armand Trousseau Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Allergology H\u00f4pital d\u2019Enfants Armand Trousseau APHP Paris France"},{"name":"Equipe EPAR Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique UMR_S1136 INSERM Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Saint\u2010Pierre","sequence":"additional","affiliation":[{"name":"Institute of Mathematics Toulouse III Paul\u2010Sabatier University Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6497-4830","authenticated-orcid":false,"given":"M\u00e9lisande","family":"Bourgoin\u2010Heck","sequence":"additional","affiliation":[{"name":"Department of Allergology H\u00f4pital d\u2019Enfants Armand Trousseau APHP Paris France"},{"name":"Equipe EPAR Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique UMR_S1136 INSERM Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention.2020. 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