{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:38:47Z","timestamp":1790401127547,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral immunotherapy is a frequent treatment for the management of food allergies, but adverse events (AE) are common. This study assessed the outcome of cow's milk oral immunotherapy (MOIT) in severe cow`s milk\u2013allergic patients treated with omalizumab in a real\u2010life setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>OmaBASE was a national, multicenter, open, and observational registry that collected clinical, immunologic, and treatment from patients with food allergy receiving omalizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data derived from 58 patients aged 10.3\u00a0years (IQR 6.3\u201013.2) and median milk\u2010specific IgE 100\u00a0kU<jats:sub>A<\/jats:sub>\/L at the start of omalizumab treatment. Most had experienced anaphylaxis by accidental exposures (70.7%) and had asthma (81.0%). Omalizumab in monotherapy induced tolerance to \u22656000\u00a0mg of cow's milk protein (CMP) to 34.8% of patients tested by oral food challenge. Omalizumab combined with MOIT conferred desensitization to \u22656000\u00a0mg of CMP to 83.0% of patients. Omalizumab withdrawal triggered more AE (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.013) and anaphylaxis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) than no discontinuation. Anaphylaxis was observed in 36.4% of patients who discontinued omalizumab, and more in those with sudden (50.0%) rather than progressive (12.5%) discontinuation. At database closure, 40.5% of patients who had completed follow\u2010up tolerated CMP without omalizumab (7.2% 1500\u20104500\u00a0mg; 33.3% \u22656000\u00a0mg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Milk oral immunotherapy initiated under omalizumab allows the desensitization of subjects with severe cow's milk allergy even after omalizumab discontinuation. However, discontinuation of omalizumab can lead to severe AE and should be carefully monitored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13517","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T13:15:10Z","timestamp":1617974110000},"page":"1287-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Oral immunotherapy in severe cow\u2019s milk allergic patients treated with omalizumab: Real life survey from a Spanish registry"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-5121","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Ib\u00e1\u00f1ez\u2010Sand\u00edn","sequence":"first","affiliation":[{"name":"Department of Allergy Hospital Infantil Universitario Ni\u00f1o Jes\u00fas and ARADyAL\u2010 RETICs network RD16\/0006\/0026 Instituto de Salud Carlos III, IIS\u2010P, FibHNJ  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Escudero","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Infantil Universitario Ni\u00f1o Jes\u00fas and ARADyAL\u2010 RETICs network RD16\/0006\/0026 Instituto de Salud Carlos III, IIS\u2010P, FibHNJ  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Cand\u00f3n Morillo","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital General La Mancha Centro  Alc\u00e1zar de San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Lasa","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Unit Hospital Universitario Donostia  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"March\u00e1n\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Allergy Complejo Hospitalario Universitario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"S\u00e1nchez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Infantil Universitario Ni\u00f1o Jes\u00fas and ARADyAL\u2010 RETICs network RD16\/0006\/0026 Instituto de Salud Carlos III, IIS\u2010P, FibHNJ  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Terrados","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonz\u00e1lez D\u00edaz","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Unit Basurto University Hospital Biocruces Bizkaia Health Research Institute  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonsoles","family":"Juste","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Martorell","sequence":"additional","affiliation":[{"name":"Department of Allergy University General Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"G\u00e1zquez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Universitari Joan XXIII Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ram\u00edrez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Food Safety Unit Department of Allergy Hospital Universitario Virgen Macarena  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Abell\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Universitario Los Arcos del Mar Menor  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda D.","family":"Martos Calahorro","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Universitario de Torrevieja  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Tabar","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Complex of Navarra  Pamplona Spain"},{"name":"Navarra Institute for Health Research (IdiSNA)  Pamplona Spain"},{"name":"Cooperative Health Research Thematic Networks (RETICs) for Asthma Adverse Reactions to drugs and Allergy (ARADYAL) Research Network  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Bartra","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Clinic, IDIBAPS Universitat de Barcelona and ARAdyAL  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-6799","authenticated-orcid":false,"given":"Rosa","family":"Garc\u00eda Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital General Universitario de Ciudad Real  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"G\u00f3mez Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Allergy Althaia, Xarxa Assistencial Universit\u00e0ria de Manresa  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-1829","authenticated-orcid":false,"given":"Mar\u00eda Flora","family":"Mart\u00edn\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Infantil Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Meseguer Arce","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Miralles","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital General Universitario Reina Sof\u00eda  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Montoro de Francisco","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Central de la Defensa G\u00f3mez Ulla  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Poza Guedes","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Universitario de Canarias  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Rodr\u00edguez del R\u00edo","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Infantil Universitario Ni\u00f1o Jes\u00fas and ARADyAL\u2010 RETICs network RD16\/0006\/0026 Instituto de Salud Carlos III, IIS\u2010P, FibHNJ  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The OmaBASE task force (Pediatric Allergy Committee, Spanish Society of Allergy and Clinical Immunology)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12630"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.060"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.979"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13124"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.029"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022613"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3304"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.051"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.046"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-015-0084-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12567"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.028"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16730-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0316-x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13084"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.01.023"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03749.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.03.015"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.030"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:36:09Z","timestamp":1692948969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13517"}},"subtitle":[],"editor":[{"given":"Alexandra","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/pai.13517"],"URL":"https:\/\/doi.org\/10.1111\/pai.13517","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]},"assertion":[{"value":"2020-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}