{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:22Z","timestamp":1772160862799,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children with allergic clinical manifestations tend to have behavioral or emotional problems such as hyperactivity or worse mental health. However, previous studies on this association did not adequately adjust for confounders like parenting stress, demographic characteristics, or allergy presentation. This study aimed to investigate the relationship between childhood allergic clinical manifestations and behavioral problems, adjusting for confounders such as demographic characteristics, parenting stress, and allergy\u2010related variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted an online cross\u2010sectional survey among caregivers of children aged 2\u20136\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0633). The Strengths and Difficulties Questionnaire (SDQ) was used to determine children's behavioral characteristics as the primary outcome. Allergic clinical manifestations, wheeze, rash, and nose symptoms were the exposure variables. Associations were estimated using logistic regression analyses with propensity scores to adjust for confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 633 caregivers of children aged 2\u20136\u00a0years (valid rate, 61.5%). Univariate analyses showed that wheezing was associated with conduct problems (odds ratio [OR]\u00a0=\u00a01.48, 95% confidence interval [CI]:1.01\u20132.16), a behavioral component of the SDQ. Rash was also associated with hyperactivity (OR\u00a0=\u00a01.62, 95% CI: 1.02\u20132.57). Furthermore, nose symptoms were associated with conduct problems (OR\u00a0=\u00a01.65, 95% CI:1.16\u20132.33) and emotional symptoms (OR=1.62, 95% CI:1.06\u20132.45). After adjusting for potential confounders, wheezing (adjusted OR\u00a0=\u00a01.69, 95% CI:1.04\u20132.75) and nose symptoms (adjusted OR\u00a0=\u00a01.56, 95% CI: 1.05\u20132.34) remained associated with conduct problems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed that a history of wheezing and nose symptoms in children is associated with an increased risk of behavioral problems, in particular, conduct problems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13542","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T05:05:38Z","timestamp":1621314338000},"page":"1646-1653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Do allergic clinical manifestations increase the risk of behavioral problems in children? A cross\u2010sectional study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-2438","authenticated-orcid":false,"given":"Chikae","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Community Health Nursing Nagoya City University Graduate School of Nursing Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-1058","authenticated-orcid":false,"given":"Takeshi","family":"Ebara","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-9649","authenticated-orcid":false,"given":"Masaki","family":"Futamura","sequence":"additional","affiliation":[{"name":"Division of Pediatrics National Hospital Organization Nagoya Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-3942","authenticated-orcid":false,"given":"Yukihiro","family":"Ohya","sequence":"additional","affiliation":[{"name":"Allergy Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-574X","authenticated-orcid":false,"given":"Midori","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Integrated Health Sciences Nursing Sciences Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2001.00002.x-i1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70536-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13417"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012637"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.02.009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.055"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14697"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.041"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.12.063"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.136"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1281-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200112000-00011"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12087"},{"issue":"1","key":"e_1_2_11_17_1","first-page":"57","article-title":"Association between allergic sensitization and attention deficit hyperactivity disorder (ADHD)","volume":"29","author":"Suwan P","year":"2011","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2011.11.008"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13876"},{"key":"e_1_2_11_20_1","unstructured":"The International Study of Asthma and Allergies in Childhood.http:\/\/isaac.auckland.ac.nz. 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