{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:07:33Z","timestamp":1782882453310,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory symptoms after exercise are frequently reported by asthmatic patients, and exercise\u2010induced bronchoconstriction (EIB) is a frequent cause, which requires objective testing for diagnosis. Eucapnic voluntary hyperpnea (EVH) is recommended as a surrogate stimulus for this purpose. Its short\u2010term reproducibility is not yet established in children and young adolescents with asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the short\u2010term test\u2010retest agreement and reproducibility of FEV\n                      <jats:sub>1<\/jats:sub>\n                      changes after EVH in this population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Asthmatic patients aged between 10 and 20\u00a0years underwent EVH for EIB diagnosis on two occasions 2\u20134\u00a0days apart at a specialized university clinic. FEV\n                      <jats:sub>1<\/jats:sub>\n                      was measured at 5, 15, and 30\u00a0min after EVH with a target ventilation rate 21 times the baseline FEV\n                      <jats:sub>1<\/jats:sub>\n                      . EIB was diagnosed as a decrease \u226510% in FEV\n                      <jats:sub>1<\/jats:sub>\n                      from baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 26 of 62 recruited individuals tested positive for EIB on both visits (positive group) and 17 on one visit only (divergent group), while 19 tested negative on both visits (negative group). The overall agreement was 72.5% (95%CI 61.6%, 83.6%), and Cohen's kappa coefficient was 0.452. Low bias (0.87%) and high intra\u2010class correlation coefficient (0.854, 95%CI 0.758,0.912;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.001) for FEV\n                      <jats:sub>1<\/jats:sub>\n                      response between test days were found, but with wide limits of agreement (\u00b120.72%). There were no differences in pre\u2010challenge FEV\n                      <jats:sub>1<\/jats:sub>\n                      or achieved ventilation rate between visits either between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.097 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.461) or within groups (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.828 and\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.780). There were no safety issues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>More than one EVH test should be performed in children and young adolescents with asthma to exclude EIB and minimize misdiagnosis and mistreatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13610","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T15:15:21Z","timestamp":1627571721000},"page":"1700-1708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reproducibility of eucapnic voluntary hyperpnoea for exercise\u2010induced bronchoconstriction diagnosis in asthmatic children and adolescents"],"prefix":"10.1111","volume":"32","author":[{"given":"Jose \u00c2ngelo","family":"Rizzo","sequence":"first","affiliation":[{"name":"Center for allergy and clinical immunology research and pulmonology department at Hospital das Cl\u00ednicas Universidade Federal de Pernambuco Recife Brazil"},{"name":"Infant and adolescent health post\u2010graduation program Universidade Federal de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-3658","authenticated-orcid":false,"given":"Edil de Albuquerque","family":"Rodrigues Filho","sequence":"additional","affiliation":[{"name":"Center for allergy and clinical immunology research and pulmonology department at Hospital das Cl\u00ednicas Universidade Federal de Pernambuco Recife Brazil"},{"name":"Infant and adolescent health post\u2010graduation program Universidade Federal de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Velozo","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Center for allergy and clinical immunology research and pulmonology department at Hospital das Cl\u00ednicas Universidade Federal de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laienne Carla Barbosa De Barros","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Center for allergy and clinical immunology research and pulmonology department at Hospital das Cl\u00ednicas Universidade Federal de Pernambuco Recife Brazil"},{"name":"Hebiatrics post\u2010graduation program Universidade de Pernambuco Recife, Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Martins de","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Center for allergy and clinical immunology research and pulmonology department at Hospital das Cl\u00ednicas Universidade Federal de Pernambuco Recife Brazil"},{"name":"Hebiatrics post\u2010graduation program Universidade de Pernambuco Recife, Pernambuco 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