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On the other hand, type 2 response\u2010activated immune cells may become dysregulated or chronically activated, causing tissue fibrosis. Among the type 2 cytokine\u2010driven inflammatory pathways, the transforming growth factor \u03b2 (TGF\u03b2), interleukin (IL)\u201017, IL\u201033, and IL\u201013\u00a0have been identified as essential mediators in patients suffering from CF. Given their critical role, we firmly believe that an adequate comprehension of the type 2\u2010mediated pathways can identify attractive targets to decrease pharmacologically the inflammation and fibrosis occurring in the pulmonary tissue of patients suffering from CF.<\/jats:p>","DOI":"10.1111\/pai.13619","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T06:35:52Z","timestamp":1643178952000},"page":"15-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Type 2 inflammation in cystic fibrosis: New insights"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-3083","authenticated-orcid":false,"given":"Sara","family":"Manti","sequence":"first","affiliation":[{"name":"Pediatric Respiratory Unit Department of Clinical and Experimental Medicine San Marco Hospital University of Catania  Catania 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