{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:58:06Z","timestamp":1778072286536,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"S27","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary atopic disorders (PADs) are monogenic diseases characterized by allergy or atopy\u2010related symptoms as fundamental features. In patients with PADs, primary immune deficiency and immune dysregulation symptoms are usually coexist. Chronic skin disease, manifesting with erythroderma, severe atopic dermatitis or eczema, and urticaria, is one of the main features observed in PADs, such as hyper\u2010IgE syndromes, Omenn syndrome, Wiskott\u2010Aldrich syndrome, IPEX\u2010linked syndrome, skin barrier disorders, as well as some autoinflammatory diseases. The recognition of PADs in the context of an allergic phenotype is crucial to ensure prompt diagnosis and appropriate treatment. This article provides an overview of the main PADs with skin involvement.<\/jats:p>","DOI":"10.1111\/pai.13633","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T06:29:21Z","timestamp":1643178561000},"page":"65-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Primary atopic disorders and chronic skin disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Bianca Laura","family":"Cinicola","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine Sapienza University of Rome  Rome Italy"},{"name":"Department of Maternal Infantile and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Corrente","sequence":"additional","affiliation":[{"name":"Division of Pediatrics S. Camillo\u2010Forlanini Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-9383","authenticated-orcid":false,"given":"Riccardo","family":"Castagnoli","sequence":"additional","affiliation":[{"name":"Pediatric Clinic Fondazione IRCCS Policlinico San Matteo University of Pavia  Pavia Italy"},{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"},{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-9533","authenticated-orcid":false,"given":"Vassilios","family":"Lougaris","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli University of Brescia and ASST\u2010Spedali Civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-9527","authenticated-orcid":false,"given":"Giuliana","family":"Giardino","sequence":"additional","affiliation":[{"name":"Pediatric Section Department of Translational Medical Sciences Federico II University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2554-1263","authenticated-orcid":false,"given":"Lucia","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-868X","authenticated-orcid":false,"given":"Stefano","family":"Volpi","sequence":"additional","affiliation":[{"name":"Center for Autoinflammatory Diseases and Immunodeficiency IRCCS Istituto Giannina Gaslini Universit\u00e0 degli Studi di Genova  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-2900","authenticated-orcid":false,"given":"Francesco","family":"La Torre","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Giovanni XXIII Pediatric Hospital University of Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7780-6430","authenticated-orcid":false,"given":"Silvia","family":"Federici","sequence":"additional","affiliation":[{"name":"Division of Rheumatology IRCCS Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarosa","family":"Soresina","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Immunology Pediatrics Clinic University of Brescia ASST\u2010Spedali Civili Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8410-9617","authenticated-orcid":false,"given":"Caterina","family":"Cancrini","sequence":"additional","affiliation":[{"name":"Academic Department of Pediatrics (DPUO) Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"},{"name":"Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-0159","authenticated-orcid":false,"given":"Gian Luigi","family":"Marseglia","sequence":"additional","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"},{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cardinale","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Giovanni XXIII Pediatric Hospital University of Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Immunology Task Force of the Italian Society of Pediatric Allergy, Immunology (SIAIP)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041553"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06096"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2021.100513"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172306"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.02.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85129"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.03.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2016.12.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.12.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010219137"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:01:32Z","timestamp":1692824492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13633"}},"subtitle":[],"editor":[{"given":"Amelia","family":"Licari","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":10,"journal-issue":{"issue":"S27","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/pai.13633"],"URL":"https:\/\/doi.org\/10.1111\/pai.13633","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}