{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T07:56:00Z","timestamp":1789286160521,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903311"],"award-info":[{"award-number":["81903311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maternal pre\u2010pregnancy body mass index (BMI) and gestational weight gain (GWG) have been linked to offspring allergic disorders. However, associations observed in previous studies were inconsistent and might be confounded by unmeasured familial factors. We aimed to examine the associations of maternal weight with offspring allergic disorders by using paternal BMI as a negative control exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included the data of 10,522 children from the Born in Guangzhou Cohort Study, 2012\u20132017. Data on maternal weight were obtained from questionnaires and obstetric records, and paternal weight was collected from questionnaires. Atopic dermatitis (AD) and wheezing at the age of 1\u00a0year were defined according to parent\u2010reported physician diagnosis. Risk ratios (RRs) were estimated by log\u2010binominal regression with mutual adjustment for maternal and paternal weight status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By the age of 1\u00a0year, 16.2% and 7.9% of children were diagnosed with AD and wheezing, respectively. While maternal pre\u2010pregnancy BMI as a continuous variable was not associated with offspring AD, infants of pre\u2010pregnancy overweight\/obese women had a higher risk of AD than those born to normal weight women; no such associations were observed for paternal BMI. Both maternal pre\u2010pregnancy BMI and paternal BMI were positively associated with the risk of offspring wheezing. Maternal GWG was not associated with AD or wheezing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that maternal pre\u2010pregnancy overweight\/obesity might increase the risk of infant AD via intrauterine mechanisms, whereas the association with wheezing might be confounded by uncontrolled familial factors. These findings may be valuable in early\u2010life prevention for offspring allergic diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13703","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T07:28:00Z","timestamp":1637566080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Associations of maternal weight status with the risk of offspring atopic dermatitis and wheezing by 1\u00a0year of age"],"prefix":"10.1111","volume":"33","author":[{"given":"Xueling","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"},{"name":"Department of Women's Health, Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangdong China"},{"name":"Provincial Clinical Research Center for Child Health  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"},{"name":"Department of Women's Health, Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangdong China"},{"name":"Provincial Clinical Research Center for Child Health  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"},{"name":"Department of Women's Health, Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou Women and Children's Medical Center 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Woman and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangdong China"},{"name":"Provincial Clinical Research Center for Child Health  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"},{"name":"Department of Women's Health, Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangdong China"},{"name":"Provincial Clinical Research Center for Child Health  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou 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