{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T18:21:04Z","timestamp":1775758864415,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T00:00:00Z","timestamp":1638576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1006215"],"award-info":[{"award-number":["GNT1006215"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1129224"],"award-info":[{"award-number":["GNT1129224"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1129228"],"award-info":[{"award-number":["GNT1129228"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Measurement of cashew\u2010specific IgE (sIgE) is often used to confirm sensitization but does not reliably diagnose clinical allergy. Ana o 3 is the dominant cashew allergen detected in 75\u2013100% of patients with cashew allergy but not currently used in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if component\u2010resolved diagnostics using specific IgE to the 2 S albumin from cashew, Ana o 3, improves the accuracy of diagnosing cashew allergy, thereby circumventing the need for an oral food challenge (OFC) in some patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A population\u2010based sample of 5276 children was recruited at age 1\u00a0year and followed up at age 6 years. Children with positive cashew skin prick test at age 6 underwent an OFC to clarify allergy status. Forty\u2010seven children (mean age 5.02\u00a0\u00b1\u00a00.2) (33 cashew\u2010allergic and 14 cashew\u2010tolerant) had cashew sIgE and Ana o 3 sIgE quantified by ImmunoCAP System FEIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A cutoff of &gt;0.32\u00a0kUA\/L for Ana o 3 sIgE provided 95% specificity and 90% sensitivity and correctly identified 90% of clinical cashew allergy. At the same specificity, the sensitivity for cashew sIgE (&gt;8.5\u00a0kUA\/L) was only 26%. Sequential measurement of cashew sIgE followed by Ana o 3 sIgE diagnosed 90% of children with cashew allergy without the need for an OFC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ana o 3 sIgE testing provides higher diagnostic accuracy than cashew sIgE. Sequential measurement of cashew sIgE followed by Ana o 3 removed the need for a food challenge from 66% down to 12.8% (5\u2010fold) of children compared with cashew sIgE testing alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13705","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T11:51:21Z","timestamp":1637841081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ana o 3 sIgE testing increases the accuracy of cashew allergy diagnosis using a two\u2010step model"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-5582","authenticated-orcid":false,"given":"Thanh D.","family":"Dang","sequence":"first","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"},{"name":"Centre for Food &amp; Allergy Research  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-6628","authenticated-orcid":false,"given":"Rachel","family":"Peters","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"},{"name":"Centre for Food &amp; Allergy Research  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie R.","family":"Neeland","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Brettig","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"},{"name":"Centre for Food &amp; Allergy Research  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayden","family":"Green","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"McWilliam","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"},{"name":"Centre for Food &amp; Allergy Research  Melbourne Victoria Australia"},{"name":"Department of Allergy and Immunology Royal Children\u2019s Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi L. K.","family":"Tang","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"},{"name":"Centre for Food &amp; Allergy Research  Melbourne Victoria Australia"},{"name":"Department of Allergy and Immunology Royal Children\u2019s Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyamali","family":"Dharmage","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"},{"name":"Centre for Food &amp; Allergy Research  Melbourne Victoria Australia"},{"name":"The Allergy and Lung Health Unit for Epidemiology and Biostatistics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Louise","family":"Ponsonby","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute  Melbourne Victoria Australia"},{"name":"Centre for Food &amp; 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