{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:50:38Z","timestamp":1779367838901,"version":"3.53.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009732","name":"Alli Paasikiven S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004037","name":"Juho Vainion S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009094","name":"Turun Yliopistollisen Keskussairaalan Koulutus- ja Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004022","name":"Jenny ja Antti Wihurin Rahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["134950"],"award-info":[{"award-number":["134950"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["308176"],"award-info":[{"award-number":["308176"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["325292"],"award-info":[{"award-number":["325292"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013499","name":"Allergias\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013499","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004325","name":"Signe ja Ane Gyllenbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008413","name":"Instrumentariumin Tiedes\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008320","name":"Suomen Aivos\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exposure to prenatal maternal psychological distress may contribute to the development of childhood atopic disorders. Little is known about the importance of distress severity and its duration for the risk. Our aim was to investigate how chronic maternal depressive and anxiety symptoms across gestation influence the risk of wheezing and eczema at child age 24\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population was drawn from the FinnBrain Birth Cohort Study, including 1305\u00a0mother\u2010infant dyads followed across gestation until the child age of 24\u00a0months when the outcomes were mother\u2010reported wheezing ever and doctor\u2010diagnosed eczema. To investigate the risk of wheezing phenotypes, wheezing with and without eczema was separated. Maternal distress was assessed with the Edinburgh Postnatal Depression Scale for depressive and the Symptom Checklist\u201090 for anxiety symptoms three times during pregnancy, and the chronicity was demonstrated using symptom trajectories composed by latent growth mixture modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the children, 219\/1305 (17%) had wheezing ever and 285\/1276 (22%) had eczema. Risk of wheezing ever was elevated with maternal consistently high depressive symptoms (adjusted odds ratio 2.74; 95% confidence interval 1.37\u20135.50) or moderate and increasing anxiety symptoms (1.94; 1.06\u20133.54, respectively). Similarly, wheezing without eczema was associated with consistently high depressive (3.60; 1.63\u20137.94, respectively) and moderate and increasing anxiety symptoms (2.43; 1.21\u20134.91, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Maternal chronic psychological distress across gestation was associated with toddler wheezing and especially wheezing without other atopic features (eczema). This finding supports the theory of intrauterine programming effect by maternal psychological distress on offspring immune system and respiratory morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13706","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:43:19Z","timestamp":1638272599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal prenatal psychological distress associates with offspring early\u2010life wheezing \u2013 FinnBrain Birth Cohort"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-9353","authenticated-orcid":false,"given":"Emma","family":"Puosi","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine FinnBrain Birth Cohort Study Turku Brain and Mind Center University of Turku  Turku Finland"},{"name":"The Department of Pediatrics and Adolescent Medicine University of Turku, and Turku University Hospital  Turku Finland"},{"name":"Centre for Population Health Research University of Turku, and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Korhonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine FinnBrain Birth Cohort Study Turku Brain and Mind Center University of Turku  Turku Finland"},{"name":"The Department of Pediatrics and Adolescent Medicine University of Turku, and Turku University Hospital  Turku Finland"},{"name":"Centre for Population Health Research University of Turku, and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine FinnBrain Birth Cohort Study Turku Brain and Mind Center University of Turku  Turku Finland"},{"name":"Centre for Population Health Research University of Turku, and Turku University Hospital  Turku Finland"},{"name":"The Department of Psychiatry University of Turku, and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva\u2010Leena","family":"Kataja","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine FinnBrain Birth Cohort Study Turku Brain and Mind Center University of Turku  Turku Finland"},{"name":"Centre for Population Health Research University of Turku, and Turku University Hospital  Turku Finland"},{"name":"The Department of Psychology University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Lukkarinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine FinnBrain Birth Cohort Study Turku Brain and Mind Center University of Turku  Turku Finland"},{"name":"The Department of Pediatrics and Adolescent Medicine University of Turku, and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasse","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine FinnBrain Birth Cohort Study Turku Brain and Mind Center University of Turku  Turku Finland"},{"name":"Centre for Population Health Research University of Turku, and Turku University Hospital  Turku Finland"},{"name":"The Department of Psychiatry University of Turku, and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-5505","authenticated-orcid":false,"given":"Minna","family":"Lukkarinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine FinnBrain Birth Cohort Study Turku Brain and Mind Center University of Turku  Turku Finland"},{"name":"The Department of Pediatrics and Adolescent Medicine University of Turku, and Turku University Hospital  Turku Finland"},{"name":"Centre for Population Health Research University of Turku, and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00156\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13091"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.01.042"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.033"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2013.876404"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12762"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.044"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12195"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12453"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102809"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.020"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103038.2011.01177.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000421"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13449"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103038.2012.01346.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.03.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjpcrm.2015.77"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201\u20100162OC"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.12.025"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx173"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.06.043"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2010.07.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207856"},{"key":"e_1_2_11_25_1","volume-title":"Mplus User's Guide","author":"Muth\u00e9n L","year":"2012"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13320"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.12.050"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.991"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12078"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12108"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00150\u20102016"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:29:22Z","timestamp":1692952162000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13706"}},"subtitle":[],"editor":[{"given":"Jon","family":"Genuneit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,5]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/pai.13706"],"URL":"https:\/\/doi.org\/10.1111\/pai.13706","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.13706\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13706\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13706\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13706\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13706\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13706\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13706\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13706\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,5]]},"assertion":[{"value":"2021-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13706"}}