{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:21:01Z","timestamp":1790688061886,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["35721032"],"award-info":[{"award-number":["35721032"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["DK\u2010W1248"],"award-info":[{"award-number":["DK\u2010W1248"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While children usually experience a mild course of COVID\u201019, and a severe disease is more common in adults, the features, specificities, and functionality of the SARS\u2010CoV\u20102\u2010specific antibody response in the pediatric population are of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a detailed analysis of IgG antibodies specific for SARS\u2010CoV\u20102\u2010derived antigens S and RBD by ELISA in 26 SARS\u2010CoV\u20102\u00a0seropositive schoolchildren with mild or asymptomatic disease course, and in an equally sized, age\u2010 and gender\u2010matched control group. Furthermore, a detailed mapping of IgG reactivity to a panel of microarrayed SARS\u2010CoV\u20102 proteins and S\u2010derived peptides was performed by microarray technology. The capacity of the antibody response to block RBD\u2010ACE2 binding and virus neutralization were assessed. Results were compared with those obtained in an adult COVID\u201019 convalescent population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After mild COVID\u201019, anti\u2010S and RBD\u2010specific IgG antibodies were developed by 100% and 84.6% of pediatric subjects, respectively. No difference was observed in regards to symptoms and gender. Mounted antibodies recognized conformational epitopes of the spike protein and were capable to neutralize the virus up to a titer of \u226580 and to inhibit the ACE2\u2010RBD interaction by up to 65%. SARS\u2010CoV\u20102\u2010specific IgG responses in children were comparable to mildly affected adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SARS\u2010CoV\u20102 asymptomatic and mildly affected pediatric patients develop a SARS\u2010CoV\u20102\u2010specific antibody response, which is comparable regarding antigen, epitope recognition, and the ability to inhibit the RBD\u2010ACE2 interaction to that observed in adult patients after mild COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13737","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T09:33:37Z","timestamp":1645436017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of the antibody response to SARS\u2010CoV\u20102 in a mildly affected pediatric population"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-3352","authenticated-orcid":false,"given":"Sonja","family":"Kopanja","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology, Allergy and Endocrinology Department of Pediatrics and Adolescent Medicine Comprehensive Centre of Pediatrics Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Gattinger","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Division of Immunopathology Centre for Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Schmidthaler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Allergy and Endocrinology Department of Pediatrics and Adolescent Medicine Comprehensive Centre of Pediatrics Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-8801","authenticated-orcid":false,"given":"Justyna","family":"Sieber","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Allergy and Endocrinology Department of Pediatrics and Adolescent Medicine Comprehensive Centre of Pediatrics Medical University of Vienna Vienna Austria"},{"name":"Department of Clinical Immunology Wroclaw Medical University Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Niepodziana","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Division of Immunopathology Centre for Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schlederer","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Division of Immunopathology Centre for Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Weseslindtner","sequence":"additional","affiliation":[{"name":"Centre for Virology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Stiasny","sequence":"additional","affiliation":[{"name":"Centre for Virology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"G\u00f6tzinger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Klinik Ottakring Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried F.","family":"Pickl","sequence":"additional","affiliation":[{"name":"Institute of Immunology Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"},{"name":"Karl Landsteiner University of Health Sciences Krems Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-7884","authenticated-orcid":false,"given":"Thomas","family":"Frischer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Klinik Ottakring Vienna Austria"},{"name":"Sigmund Freud Private University Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-3365","authenticated-orcid":false,"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Division of 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