{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:23:24Z","timestamp":1790270604194,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cold urticaria (coldU) is associated with substantial morbidity and risk of fatality. Data on coldU in children are sparse. We aimed to evaluate the clinical characteristics, management, risk of associated anaphylaxis, and resolution rate of coldU in a pediatric cohort. Additionally, we sought to compare these metrics to children with chronic spontaneous urticaria (CSU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled children with coldU from 2013\u20132021 in a cohort study at the Montreal Children's Hospital and an affiliated allergy clinic. Data for comparison with participants with solely CSU were extracted from a previous study. Data on demographics, comorbidities, severity of presentation, management, and laboratory values were collected at study entry. Patients were contacted yearly to assess for resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two children with cold urticaria were recruited, 51.9% were female and the median age of symptom onset was 9.5\u00a0years. Most patients were managed with second\u2010generation H1\u2010antihistamines (sgAHs). Well\u2010controlled disease on sgAHs was negatively associated with concomitant CSU (adjusted odds ratio (aOR)\u00a0=\u00a00.69 [95%CI: 0.53, 0.92]). Elevated eosinophils were associated with cold\u2010induced anaphylaxis (coldA; aOR\u00a0=\u00a01.38 [95%CI: 1.04, 1.83]), which occurred in 17.3% of patients. The resolution rate of coldU was 4.8 per 100 patient\u2010years, which was lower than that of CSU (adjusted hazard ratio\u00a0=\u00a00.43 [95%CI: 0.21, 0.89], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22122<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pediatric coldU bears a substantial risk of anaphylaxis and a low\u2010resolution rate. Absolute eosinophil count and co\u2010existing CSU may be useful predictive factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13751","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T06:25:46Z","timestamp":1646375146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cold urticaria in a pediatric cohort: Clinical characteristics, management, and natural history"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-220X","authenticated-orcid":false,"given":"Connor","family":"Prosty","sequence":"first","affiliation":[{"name":"Faculty of Medicine McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-1081","authenticated-orcid":false,"given":"Sofianne","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine McGill University  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