{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:26Z","timestamp":1772160866970,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effects of infection and developmental adaptations in infancy on the prevalence of subsequent atopy\u2010related diseases at different ages during childhood are not fully determined. This study aims to examine the similarities and differences in the age\u2010specific association of asthma, allergic rhinitis\/conjunctivitis, and atopic dermatitis with early\u2010life infection\u2010related factors (i.e., daycare, older siblings, and severe airway infection) and developmental adaptations (i.e., preterm birth and rapid weight gain) in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this longitudinal cohort study (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a047,015), children were followed from 0.5 to 11\u00a0years. The potential risks and protective factors, including daycare attendance at 0.5\u00a0years, existence of older siblings, history of hospitalization due to cold\/bronchitis\/bronchiolitis\/pneumonia during 0.5\u20131.5\u00a0years, preterm birth, and rapid weight gain in the first 2.5\u00a0years, were assessed using multivariable logistic regression with adjustments for potential confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A protective association was observed between early\u2010life daycare attendance and asthma at 5.5\u20139\u00a0years, which disappeared after 10\u00a0years. A protective association was also noted throughout childhood between early daycare attendance and older siblings with allergic rhinitis\/conjunctivitis. However, the association between early daycare and atopic dermatitis was found to be risky during childhood. In contrast, the early\u2010life history of hospitalization owing to cold\/bronchitis\/bronchiolitis\/pneumonia was identified to be a risk factor for developing both asthma and allergic rhinitis\/conjunctivitis. Preterm birth was a significant risk factor for childhood asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Different age\u2010specific patterns were demonstrated in the relationship between early daycare, severe airway infection, preterm birth, and atopy\u2010related diseases in childhood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13771","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T11:23:09Z","timestamp":1649676189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Age\u2010specific associations of early daycare, older siblings, severe airway infection, and preterm birth with subsequent atopic diseases"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-7841","authenticated-orcid":false,"given":"Tadao","family":"Nagasaki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Tabuchi","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Cancer Control Center Osaka International Cancer Institute  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisako","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine &amp; Allergology Faculty of Medicine Kindai University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Horimukai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jikei University Katsushika 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