{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T22:57:30Z","timestamp":1778367450647,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["428057545"],"award-info":[{"award-number":["428057545"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EA2107B"],"award-info":[{"award-number":["01EA2107B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GL1742C"],"award-info":[{"award-number":["01GL1742C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peanut and tree nut allergies are common in childhood and often severe in nature. The clinical picture shows a wide variety of symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the distribution of clinical symptoms and severity during oral food challenges (OFC) in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Analysis of 1.013 prospectively recorded, positive OFCs with peanut (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0607), hazelnut (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0266), walnut (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a097), and cashew (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a043). Symptoms were categorized as immediate\u2010type skin, gastrointestinal, upper and lower respiratory, cardiovascular symptoms, and eczema exacerbation. Symptom severity and treatment were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Skin symptoms presented in 78%, followed by gastrointestinal (47%), upper (42%), and lower respiratory symptoms (32%). Cardiovascular symptoms presented in 6%. In three\u2010quarter of the reactions, more than one organ was involved. Importantly, severe reactions occurred at every dose level. Peanut\u2010 and cashew\u2010allergic patients had a higher relative risk of gastrointestinal symptoms compared with hazelnut\u2010 and walnut\u2010allergic patients. Patients without vomiting had a 1.7 times higher risk developing immediate\u2010type skin and\/or lower respiratory symptoms. Three\u2010quarter of the patients ever had eczema but worsening presented in only 10.5% of the OFCs. In patients with multiple food allergies, organs involved, eliciting dose and severity differed between allergens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although comparisons between allergen groups with different clinical history, severity, comorbidities and laboratory data are difficult and might contain bias, our data confirm the high allergenic potential of peanut and tree nuts. The rare occurrence of eczema worsening emphasizes that avoidance diets of peanuts and tree nuts to cure eczema seem to be unnecessary and may hamper tolerance maintenance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13778","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T03:12:05Z","timestamp":1652152325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Organ\u2010specific symptom patterns during oral food challenge in children with peanut and tree nut allergy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-5879","authenticated-orcid":false,"given":"Josefine","family":"Dobbertin\u2010Welsch","sequence":"first","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Staudacher","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"},{"name":"Department of Immunology Labor Berlin \u2013 Charit\u00e9 Vivantes GmbH  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song\u00fcl","family":"Y\u00fcrek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-5899","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Trendelenburg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Tschirner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Ziegert","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergology German Red Cross Clinic Westend  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital \u201cAltona\u201d  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Millner\u2010Uhlemann","sequence":"additional","affiliation":[{"name":"Pediatric allergology practice  Stuttgart"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"B\u00fcsing","sequence":"additional","affiliation":[{"name":"Children's Hospital  Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Striegel","sequence":"additional","affiliation":[{"name":"Children's Hospital University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagen","family":"Ott","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology and Allergology Children's Hospital Auf der Bult  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa","family":"Arens","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology and Allergology Children's Hospital Auf der Bult  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Gappa","sequence":"additional","affiliation":[{"name":"Children\u2018s Hospital Evangelisches Krankenhaus D\u00fcsseldorf Formerly Marien hospital Wesel  Wesel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Lange","sequence":"additional","affiliation":[{"name":"Department for Pediatrics St. Marien\u2010Hospital  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunhild","family":"Gernert","sequence":"additional","affiliation":[{"name":"Department for Pediatrics St. Marien\u2010Hospital  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodo","family":"Niggemann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"},{"name":"Department of Pediatric Allergology German Red Cross Clinic Westend  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.03.014"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12801"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12630"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.S3.1631"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.045"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000458724"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/children2030371"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.129235"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12959"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12896"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.2012.02838.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12530"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.11.015"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081\u20101206(10)61550\u20105"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.01.016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13353"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.3.e8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13104"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.2005.02150.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.017"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.007"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.035"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13778","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:18:49Z","timestamp":1692789529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/pai.13778"],"URL":"https:\/\/doi.org\/10.1111\/pai.13778","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.13778\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13778\/v1\/review2","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"2021-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13778"}}