{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:23:11Z","timestamp":1788790991297,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","award":["5295"],"award-info":[{"award-number":["5295"]}],"id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pathophysiology of atopic dermatitis (AD) is multifactorial, impacted by individual medical, demographic, environmental, and immunologic factors. This study used multi\u2010omic analyses to assess how host and microbial factors could contribute to infant AD development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This longitudinal cohort study included 129 term infants, identified as AD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037) or non\u2010AD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a092) using the Infant Feeding Practices\u2010II survey and review of medical records. Standardized surveys were used to assess medical and demographic traits (gestational age, sex, race, maternal AD, and atopy family history), and environmental exposures (delivery method, maternal tobacco use, pets, breastfeeding duration, and timing of solid food introduction). Saliva was collected at 6\u00a0months for multi\u2010omic assessment of cytokines, microRNAs, mRNAs, and the microbiome. The contribution of each factor to AD status was assessed with logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Medical, demographic, and environmental factors did not differ between AD and non\u2010AD infants. Five \u201comic\u201d factors (IL\u20108\/IL\u20106, miR\u2010375\u20103p, miR\u201021\u20105p, bacterial diversity, and Proteobacteria) differed between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The severity of AD was positively associated with levels of miR\u2010375\u20103p (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.049) and Proteobacteria (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.011), and negatively associated with levels of miR\u201021\u20105p (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.022). Multi\u2010omic features accounted for 17% of variance between groups, significantly improving an AD risk model employing medical, demographic, and environmental factors (\n                      <jats:italic>X<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a032.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interactions between the microbiome and host signaling may predispose certain infants to AD by promoting a pro\u2010inflammatory environment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13817","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T05:25:00Z","timestamp":1655184300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Understanding immunological origins of atopic dermatitis through multi\u2010omic analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0817-844X","authenticated-orcid":false,"given":"Ramin","family":"Beheshti","sequence":"first","affiliation":[{"name":"Department of Pediatrics Pennsylvania State Health Children's Hospital  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Halstead","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pennsylvania State Health Children's Hospital  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"McKeone","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pennsylvania State Health Children's Hospital  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pennsylvania State Health Children's Hospital  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8561(03)00066-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0281-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-RAI-0270"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12546"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2016.60606"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2020.1783196"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02083.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-018-0006-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8040444"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-33"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.02.009"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.75"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041314"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198288"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1315c"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.07.009"},{"key":"e_1_2_11_18_1","unstructured":"ClicknerRP MarkerD VietSM RogersJ BroeneP.National survey of lead and allergens in housing. 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