{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:00:07Z","timestamp":1788991207351,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:00:00Z","timestamp":1656806400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Diverse pathways stemming from a history of atopic dermatitis (AD) might modulate different biomarkers associated with the development of asthma. Biomarkers associated with AD and asthma separately have been investigated, but none have characterized a combined AD+asthma phenotype. We investigated the clinical and molecular characteristics associated with an AD+asthma phenotype compared with AD, asthma and controls.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n From a prospective birth cohort and the outpatient allergy clinic, we included four groups of 6\u201312\u2010year\u2010old children: (1) healthy controls (2) previous, current, or present AD without asthma, (3) previous, current, or present AD\n and<\/jats:italic>\n current asthma and (4) current asthma without AD. We performed clinical examinations and interviews and measured serum IgE, natural moisturizing factors (NMF), and plasma cytokine levels.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found an increased number of IgE sensitizations in AD+asthma, prominent after stratifying for food allergens (\n p<\/jats:italic>\n \u2009<\u2009.05). Pro\u2010Th\n 2<\/jats:sub>\n cytokines CCL18, TSLP, and Eotaxin\u20103 were elevated in AD+asthma, though not significantly higher than asthma, and elevated in asthma compared with controls. NMF levels were decreased in AD compared with asthma and control groups (\n p<\/jats:italic>\n \u00a0=\u00a0.019,\n p<\/jats:italic>\n \u2009<\u2009.001, respectively). NMF levels correlated negatively to sensitization (\n p<\/jats:italic>\n \u00a0=\u00a0.026), though nonsignificant with only the patient groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our results indicate that Th\n 2<\/jats:sub>\n cytokines and increased number of sensitizations are associated with AD\u2009+\u2009asthma phenotypes compared with AD alone and that skin barrier impairment as well as decreased airway epithelial integrity may play a role in sensitization and immune modulation. Our findings suggest candidate biomarkers that should be further explored for their functional roles and prognostic potential.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.13823","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T09:28:36Z","timestamp":1656840516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biomarkers in asthma in the context of atopic dermatitis in young children"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-2610","authenticated-orcid":false,"given":"Millie Nguyen","family":"Basu","sequence":"first","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital Odense Denmark"},{"name":"Institute of Clinical Research, Faculty of Health Sciences University of Southern Denmark Odense Denmark"},{"name":"Open Patient Data Explorative Network (OPEN) Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Kold","family":"Jensen","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital Odense Denmark"},{"name":"Open Patient Data Explorative Network (OPEN) Odense University Hospital Odense Denmark"},{"name":"Department of Pharmacology, Clinical Pharmacy and Environmental Medicine University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Barington","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research, Faculty of Health Sciences University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Immunology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate Lykke","family":"Lambertsen","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine University of Southern Denmark Odense Denmark"},{"name":"Department of Neurology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research Brain Research\u2010Inter\u2010Disciplinary Guided Excellence (BRIDGE) Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0161-8278","authenticated-orcid":false,"given":"Susanne","family":"Halken","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital Odense 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