{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:28:04Z","timestamp":1790785684545,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We prospectively evaluated the association between low\u2010carbohydrate\u2010diet (LCD) score during pregnancy and the risk of allergic diseases in infants up to 2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were from a prospective mother\u2010offspring cohort study in Wuhan, China. LCD score was calculated according to the percentage of dietary energy intake from carbohydrate, protein, and fat assessed in late pregnancy using validated food frequency questionnaires. Allergic diseases, including immunoglobulin E (IgE)\u2010mediated allergic diseases, allergic contact dermatitis, and food allergy, were recorded at 3, 6, 12, and 24\u2009months postpartum follow\u2010up. Poisson regression models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1636 mother\u2013infant pairs included in the present analysis, 230 infants (14.1%) with IgE\u2010mediated allergic diseases, 77 (4.7%) with allergic contact dermatitis, and 488 (29.8%) with food allergy were, respectively, reported. Independent of total energy intake and other potential confounders, both the lowest quintile (RR, 1.77; 95% CI, 1.13\u20132.77) and the highest quintile (RR, 1.72; 95% CI, 1.22\u20132.63), were associated with the risk of IgE\u2010mediated allergic diseases compared with the middle quintile. Among high\u2010carbohydrate\u2010diet pregnant women, substituting 5% of energy from either protein or fat for carbohydrate was associated with a lower risk of IgE\u2010mediated allergic diseases. While among low\u2010carbohydrate\u2010diet pregnant women, substituting 5% of energy from carbohydrate, especially high\u2010quality carbohydrate, for fat was associated with a lower risk of IgE\u2010mediated allergic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal low carbohydrate\u2010high protein and fat, and high carbohydrate\u2010low protein and fat diet were both associated with an increased risk of allergic diseases in the infants up to 2\u2009years. This study may provide an intervention strategy for allergy prevention in early childhood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13842","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T04:37:26Z","timestamp":1662439046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of maternal low\u2010carbohydrate\u2010diet score during pregnancy with allergic diseases at 2\u2009years of age"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-1725","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety School of Public Health, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Ministry of Education Key Laboratory of Environment and Health 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