{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:28:41Z","timestamp":1783344521577,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Legume consumption has increased during the two past decades. In France, legumes are responsible for 14.6% of food\u2010related anaphylaxis in children, with peanut as the main allergen (77.5%). Few studies have demonstrated cross\u2010reactivities between peanut and other legumes. The aim of this study was to determine prevalence and relevance of sensitization to legumes in peanut\u2010allergic children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All children, aged of 1\u201317\u2009years, admitted to the Pediatric Allergy Department of the University Hospital of Nancy between January 1, 2017 and February 29, 2020 with a confirmed peanut allergy (PA) and a documented consumption or sensitization to at least one other legume were included. Data were retrospectively collected regarding history of consumption, skin prick tests, specific immunoglobulin E (IgE), prior allergic reactions, and oral food challenges for each legume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 195 included children with PA, 122 were sensitized to at least one other legume (63.9%). Main sensitizations were for fenugreek (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a061, 66.3%), lentil (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a038, 42.2%), soy (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a061, 39.9%), and lupine (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a063, 34.2%). Among the 122 sensitized children, allergy to at least one legume was confirmed for 34 children (27.9%), including six children who had multiple legume allergies (4.9%). Lentil, lupine, and pea were the main responsible allergens. Half of allergic reactions to legumes other than peanut were severe.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The high prevalence of legume sensitization and the frequent severe reactions reported in children with PA highlight that tolerated legume consumption should be explored for each legume in the case of PA, and sensitization should be investigated if not.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13846","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T03:30:43Z","timestamp":1662607843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Relevance of sensitization to legumes in peanut\u2010allergic children"],"prefix":"10.1111","volume":"33","author":[{"given":"Tim\u00e9","family":"Muller","sequence":"first","affiliation":[{"name":"Pediatric Allergy Department, Children's Hospital University Hospital of Nancy  Vand\u0153uvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Luc","sequence":"additional","affiliation":[{"name":"DRCI, MPI Department, Methodology, Data Management and Statistics Unit University Hospital of Nancy  Vand\u0153uvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Adam","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Department, Children's Hospital University Hospital of Nancy  Vand\u0153uvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Jarlot\u2010Chevaux","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Department, Children's Hospital 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