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Our aim was to determine whether early age residential exposure to inspector\u2010observed moisture damage or mold is associated with different wheezing phenotypes later in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Building inspections were performed by civil engineers, in a standardized manner, in the children's homes\u2014mostly single family and row houses (<jats:italic>N<\/jats:italic>\u00a0=\u00a0344)\u2014in the first year of life. The children were followed up with repeated questionnaires until the age of 6\u2009years and wheezing phenotypes\u2014never\/infrequent, transient, intermediate, late onset, and persistent\u2014were defined using latent class analyses. The multinomial logistic regression model was used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 63% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0218) had infrequent or no wheeze, 23% (<jats:italic>n<\/jats:italic>\u00a0=\u00a080) had transient and 9.6% (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) had a persistent wheeze. Due to the low prevalence, results for intermediate (3.8%, <jats:italic>n<\/jats:italic>\u00a0=\u00a013) and late\u2010onset wheeze (3.5%, <jats:italic>n<\/jats:italic>\u00a0=\u00a012) were not further evaluated. Most consistent associations were observed with the persistent wheeze phenotype with an adjusted odds ratio (95% confidence intervals) 2.04 (0.67\u20136.18) for minor moisture damage with or without mold spots (present in 23.8% of homes) and 3.68 (1.04\u201313.05) for major damage or any moisture damage with visible mold in a child's main living areas (present in 13.4% of homes). Early\u2010age moisture damage or mold in the kitchen was associated with transient wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At an early age, residential exposure to moisture damage or mold, can be dose\u2010dependently associated especially with persistent wheezing phenotype later in childhood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13864","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T10:51:13Z","timestamp":1665485473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early\u2010life residential exposure to moisture damage is associated with persistent wheezing in a Finnish birth cohort"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-9484","authenticated-orcid":false,"given":"Christina","family":"Tischer","sequence":"first","affiliation":[{"name":"Institute of Clinical Epidemiology and Biometry University of Wuerzburg  Wuerzburg Germany"},{"name":"State Institute of Health, Bavarian Health and Food Safety Authority  Bad Kissingen Germany"},{"name":"Department of Health Security Finnish Institute for Health and Welfare  Kuopio Finland"},{"name":"European Foundation for the Care of Newborn Infants (EFCNI)  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"T\u00e4ubel","sequence":"additional","affiliation":[{"name":"Department of Health Security Finnish Institute for Health and Welfare  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirkka V.","family":"Kirjavainen","sequence":"additional","affiliation":[{"name":"Department of Health Security Finnish Institute for Health and Welfare  Kuopio Finland"},{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Depner","sequence":"additional","affiliation":[{"name":"Institute for Asthma and Allergy Prevention (IAP) Helmholtz Zentrum M\u00fcnchen1  Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[{"name":"Department of Health Security Finnish Institute for Health and Welfare  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eija","family":"Piippo\u2010Savolainen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital  Kuopio Finland"},{"name":"Department of Medicine University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Pekkanen","sequence":"additional","affiliation":[{"name":"Department of Health Security Finnish Institute for Health and Welfare  Kuopio Finland"},{"name":"Department of Public Health University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Karvonen","sequence":"additional","affiliation":[{"name":"Department of Health Security Finnish Institute for Health and Welfare  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307922"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002410"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00184010"},{"key":"e_1_2_12_5_1","unstructured":"World Health Organization.WHO guidelines for indoor air quality: dampness and mould. 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