{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:43:02Z","timestamp":1789612982027,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008271","name":"LEO Pharma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dupilumab has proven to be an effective and safe treatment for atopic dermatitis (AD) in pediatric patients in clinical trials. However, few daily practice studies are available. The aim of this study is to evaluate the effect of 28\u2009weeks dupilumab treatment on effectiveness, safety, and serum biomarkers in pediatric patients with moderate\u2010to\u2010severe AD in daily practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients visited the outpatient clinic at baseline, 4, 16, and 28\u2009weeks of treatment. Disease severity was assessed by the Eczema Area and Severity Index (EASI), Investigator Global Assessment (IGA), Numeric Rating Scale (NRS)\u2010pruritus and \u2010pain, and the Patient\u2010Oriented Eczema Measure (POEM). Side effects were evaluated. Nineteen severity\u2010associated serum biomarkers were measured. Predicted\u2010EASI (p\u2010EASI) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients were included. Respectively 75.4%, 49.2%, and 24.6% reached EASI\u201050, EASI\u201075, and EASI\u201090 and 36.1% achieved an IGA\u2010score (almost) clear. Improvement of \u22654 points on POEM, NRS\u2010pruritus, and NRS\u2010pain was reached by 84.7%, 45.3%, and 77.4%, respectively. Most reported side effects were conjunctivitis (<jats:italic>n<\/jats:italic>\u00a0=\u200910) and headache (<jats:italic>n<\/jats:italic>\u00a0=\u20094). Biomarkers TARC, PARC, periostin, sIL\u20102Ra, and eotaxin\u20103 significantly decreased during treatment. The p\u2010EASI showed a significant correlation with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dupilumab treatment significantly improved disease severity and disease\u2010associated symptoms and decreased severity\u2010associated serum biomarkers in pediatric AD patients in daily practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13887","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T07:16:30Z","timestamp":1670310990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dupilumab in daily practice for the treatment of pediatric atopic dermatitis: 28\u2010week clinical and biomarker results from the <scp>BioDay<\/scp> registry"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-9634","authenticated-orcid":false,"given":"Esm\u00e9","family":"Kamphuis","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-6414","authenticated-orcid":false,"given":"Celeste M.","family":"Boesjes","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Utrecht University of Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-9284","authenticated-orcid":false,"given":"Laura","family":"Loman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-5794","authenticated-orcid":false,"given":"Daphne S.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Utrecht University of Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-7851","authenticated-orcid":false,"given":"Mila","family":"Poelhekken","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4441-1448","authenticated-orcid":false,"given":"Nicolaas P. A.","family":"Zuithoff","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-2971","authenticated-orcid":false,"given":"Marijke","family":"Kamsteeg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Radboud University Medical Center Radboud University  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-8596","authenticated-orcid":false,"given":"Geertruida L. E.","family":"Romeijn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8343-1356","authenticated-orcid":false,"given":"Femke","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, University Medical Center Utrecht University of Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-6993","authenticated-orcid":false,"given":"Marjolein S.","family":"de Bruin\u2010Weller","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Utrecht University of Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-5111","authenticated-orcid":false,"given":"Marlies","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Utrecht University of Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4382","authenticated-orcid":false,"given":"Marie L. 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