{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:10:49Z","timestamp":1790838649077,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012016","name":"Nipponham Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies have reported threshold doses for food allergens. However, evidence regarding potential risk factors for low threshold doses is limited. Moreover, the relationship between threshold dose and specific immunoglobulin E (sIgE) levels to causative foods remains unclear. This study examined the relationship and the risk factors for a low threshold dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited children with food allergies and examined the risk factors for a positive oral food challenge (OFC) with a low threshold dose and anaphylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We evaluated 2501 children with food allergies (1667 [67%] boys; median age, 4.9\u2009years) to eggs (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20091096), milk (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009671), wheat (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009370), peanuts (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009258), walnuts (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200965), and cashews (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200941). Of these patients, 234 (9%) reacted to \u226430\u2009mg protein of causative foods and 620 (25%) reacted to \u2264100\u2009mg protein of causative foods. The sIgE level to causative foods was a significant independent factor for positive OFCs with a threshold dose of \u226430\u2009mg for milk, wheat, and peanuts; \u2264\u2009100\u2009mg for eggs, milk, wheat, peanuts, and cashews; and anaphylaxis from eggs, milk, wheat, peanuts, and walnuts. High sIgE levels to causative foods were associated with a lower threshold dose of the OFC and anaphylaxis during the OFC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately 9% of patients reacted to \u226430\u2009mg protein of causative foods. The potential risks of anaphylaxis should be considered during OFCs for patients with elevated sIgE levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13926","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T04:36:28Z","timestamp":1678077388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Relationship between serum allergen\u2010specific immunoglobulin E and threshold dose in an oral food challenge"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-744X","authenticated-orcid":false,"given":"Noriyuki","family":"Yanagida","sequence":"first","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology National Hospital Organization, Sagamihara National Hospital  Sagamihara Kanagawa Japan"},{"name":"Department of Pediatrics National Hospital Organization, Sagamihara National 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Pediatrics National Hospital Organization, Sagamihara National Hospital  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-8135","authenticated-orcid":false,"given":"Naoko","family":"Fusayasu","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology National Hospital Organization, Sagamihara National Hospital  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-6901","authenticated-orcid":false,"given":"Yoko","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization, Sagamihara National Hospital  Sagamihara Kanagawa 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