{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:26:14Z","timestamp":1785378374355,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence has suggested a bidirectional association between both the effects and onset of asthma and anxiety. The direction of this association in children and adolescents is less clear. The study evaluates whether anxiety in children is associated with the development of later asthma or, by contrast, whether asthma in children precedes anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Parental reports from 9369 children at two age points (4\u20135 and 14\u201315\u2009years old) and from baby (B) (recruited at birth in 2004) and kindergarten (K) (recruited at 4\u20135\u2009years of age in 2004) cohorts of the Longitudinal Study of Australian Children (LSAC) were analyzed. Asthma cases were defined as reports of doctor\u2010diagnosed asthma and the use of asthma medication or\/and wheezing. Scores of the Strengths and Difficulties Questionnaire (SDQ) defined anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found a unidirectional association between asthma in children aged 4\u20135\u2009years and future anxiety development in weighted generalized linear adjusted models (B cohort OR (CI 95%)\u00a0=\u00a01.54 (1.14\u20132.08); K cohort OR (CI 95%)\u00a0=\u00a01.87 (1.40\u20132.49)). Children with asthma (no anxiety at 4\u2009years) had a higher prevalence of anxiety in adolescence compared with nonasthmatics (B cohort\u00a0=\u00a026.8% vs 17.6%: K cohort\u00a0=\u00a027.7% vs 14.3%). Anxiety in childhood was not associated with the development of asthma from 6\u2009years old to adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Australian children with asthma have a greater risk of developing anxiety from 6 to 15\u2009years old. This suggests that early multidisciplinary intervention may be required to support children with asthma to either prevent the increased risk of anxiety and\/or promote optimal anxiety management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13941","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T03:50:34Z","timestamp":1679975434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Asthma and anxiety development in Australian children and adolescents"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-357X","authenticated-orcid":false,"given":"Diana","family":"Garcia\u2010Sanchez","sequence":"first","affiliation":[{"name":"School of Public Health The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darsy","family":"Darssan","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheleigh P.","family":"Lawler","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Warren","sequence":"additional","affiliation":[{"name":"Center for Food Allergy and Asthma Research, Department of Preventive Medicine Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"De\u00a0Klerk\u2010Braasch","sequence":"additional","affiliation":[{"name":"Ipswich Hospital  Brisbane Queensland Australia"},{"name":"West Moreton Hospital and Health Service  Brisbane Queensland Australia"},{"name":"Queensland Health  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Osborne","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland  Herston Queensland Australia"},{"name":"School of Population Health University of New South Wales  Sydney New South Wales Australia"},{"name":"European Centre for Environment and Human Health University of Exeter  Truro UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-015-0007-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-0856"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2019.10.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.02.043"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.034"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305396"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1104694"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001754"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720005097"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000161524.37575.42"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708003504"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12000"},{"key":"e_1_2_11_14_1","first-page":"1","volume-title":"Sample Design. 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