{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:42:54Z","timestamp":1780490574048,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cow's milk allergy can result in anaphylactic reactions. The estimated prevalence of cow's milk allergy in developed countries ranges from 0.5% to 3% at age 1\u2009year. Our objective was to perform a systematic review and, if possible, a meta\u2010analysis to assess the frequency of fatal and recurrent anaphylaxis induced by cow's milk. We searched PubMed\/MEDLINE, EMBASE, and the Web of Science for studies that had assessed fatal and recurrent anaphylaxis induced by cow's milk for the population of a country or at least an administrative region. Our review included cohort, cross\u2010sectional, and registry studies that had assessed the incidence or prevalence of recurrent anaphylaxis or the incidence of fatal anaphylaxis due to cow's milk. The pooled prevalence of recurrence (PR) for at least an episode of anaphylaxis was 26.98% (3.85\u2013189.1). Teymourpour et al (Iran) reported the highest PR (53.10%); the two studies with the lowest PR were from France (5.2 and 0.42, respectively) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Nine studies on fatal anaphylaxis were selected (41 deaths) and found to be highly heterogeneous (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200975.9%). Levy et al and Bassagio et al reported the highest incidence rate (IR 0.15 and 0.6 deaths per million persons\u2010year). The PR of anaphylaxis was approximately one quarter of patients with anaphylaxis due to cow's milk, while deaths from anaphylaxis caused by cow's milk were very rare, although some studies report rates as high as 15 times the lowest IR.<\/jats:p>","DOI":"10.1111\/pai.13977","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T12:28:43Z","timestamp":1688387323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["\u201cFrequency of fatal and recurrent anaphylaxis due to COW'S milk: A systematic review and meta\u2010analysis of observational studies\u201d"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2548-813X","authenticated-orcid":false,"given":"Sabela","family":"P\u00e9rez\u2010Codesido","sequence":"first","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Alcorc\u00f3n Spain"},{"name":"International Doctoral School, Facultad Ciencias de la Salud Universidad Rey Juan Carlos  Alcorc\u00f3n Spain"},{"name":"Division of immunology and Allergology University Hospitals and Medical Faculty of Geneva  Gen\u00e8ve Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulalia","family":"Grifol\u2010Clar","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianela Brandoni","family":"Petrone","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Goyanes","family":"Malumbres","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Andrade","family":"Garban","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Tejedor\u2010Alonso","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Alcorc\u00f3n Spain"},{"name":"Facultad Ciencias de la Salud, Department of Medical Specialties and Public Health Universidad Rey Juan Carlos  Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051051"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12630"},{"issue":"6","key":"e_1_2_12_4_1","first-page":"383","article-title":"Recurrence of anaphylaxis in a Spanish series","volume":"23","author":"Tejedor\u2010Alonso MA","year":"2013","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63357-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01671.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03859.x"},{"issue":"1","key":"e_1_2_12_8_1","first-page":"29","article-title":"Cow's milk anaphylaxis in children first report of Iranian food allergy registry","volume":"11","author":"Teymourpour P","year":"2012","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.1125"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3181c82128"},{"key":"e_1_2_12_11_1","unstructured":"ConradoAB IerodiakonouD GowlandMH BoyleRJ TurnerPJ.Food anaphylaxis in the United Kingdom: analysis of national data. 1998\u20132018. 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