{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:20Z","timestamp":1772160860614,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fucoxanthin, a marine xanthophyll carotenoid, has been shown to exert beneficial health effects. Cell\u2010based and animal\u2010based experimental studies have shown that fucoxanthin has the potential to mitigate eczema symptoms. Hence, we sought to assess whether fucoxanthinol 3\u2010arachidate, a fucoxanthin metabolite, measured in maternal serum at birth is associated with eczema development during early childhood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the 1989\/1990 Isle of Wight birth cohort were analyzed. We focused on data obtained from the 1, 2, and 4\u2009years follow\u2010ups. Fucoxanthinol 3\u2010arachidate was measured in maternal serum at the child's birth as abundance relative to the reference lipids. Eczema was ascertained according to parent\u2010reported clinical history and characteristic morphology and distribution. Log\u2010binomial regression models were used to estimate adjusted risk ratios (aRR) and their 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 592 subjects (49.2% males and 50.8% females) were included in the current analysis. Associations between fucoxanthinol 3\u2010arachidate levels and eczema risk during the first 4\u2009years of life (longitudinal analysis) were evaluated using four modeling approaches, which showed higher fucoxanthinol 3\u2010arachidate levels were associated with reduced eczema risk: (i) aRR\n                      <jats:sub>per 10 unit increase<\/jats:sub>\n                      \u2009=\u20090.88, 95% CI: 0.76\u20131.03; (ii) aRR\n                      <jats:sub>&gt;0 vs. =0<\/jats:sub>\n                      \u2009=\u20090.67, 0.45\u20130.99; (iii) aRR\n                      <jats:sub>\u22652.3 vs. &lt;2.3<\/jats:sub>\n                      \u2009=\u20090.66, 0.44\u20130.98; and (iv) aRR\n                      <jats:sub>tertile 3 vs. tertile 1<\/jats:sub>\n                      \u2009=\u20090.65, 0.42\u20130.99.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that increased fucoxanthinol 3\u2010arachidate levels measured in maternal serum at the child's birth is associated with reduced eczema risk during the first 4\u2009years of the offspring life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13979","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T05:48:53Z","timestamp":1687153733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fucoxanthin levels in maternal serum at birth and eczema risk in offspring in early childhood: A birth cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-4424","authenticated-orcid":false,"given":"Ali H.","family":"Ziyab","sequence":"first","affiliation":[{"name":"Department of Community Medicine and Behavioral Sciences, Faculty of Medicine Kuwait University  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Daniel","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilani M.","family":"Anthony","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fay W. Boozman College of Public Health University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Hasan","family":"Arshad","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"},{"name":"David Hide Asthma and Allergy Research Centre  Isle of Wight UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2684-1492","authenticated-orcid":false,"given":"Wilfried","family":"Karmaus","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health University of Memphis  Memphis Tennessee 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