{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:20:36Z","timestamp":1780503636929,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have shown the efficacy of the early introduction of peanut to prevent peanut allergy. Due to the exclusion of infants with sensitization to peanut, it remains unclear what the optimal timing of introduction is.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PeanutNL study was performed in 6 pediatric allergology centers in the Netherlands. Infants referred for the clinical early introduction of peanut to prevent peanut allergy underwent skin prick tests for peanut and an oral peanut challenge at a median age of 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred sixty two of 707 infants (23%) who had never eaten peanut before were sensitized to peanut, of which 80 (49%) had wheals of &gt;4\u2009mm. Sixty seven of 707 infants (9.5%) had a positive oral challenge to peanut at first introduction. Multivariate analysis revealed that age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and SCORAD eczema severity scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001) were significant risk factors. Introduction of peanut at \u22658\u2009months in infants with moderate and severe eczema resulted in an increased risk (odds ratio 5.24 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.013) and 3.61 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.019), respectively) of having reactions to peanut as compared to introduction before 8\u2009months. A family history of peanut allergy and previous reactions to egg were not identified as independent risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that peanut should be introduced before the age of 8\u2009months to reduce the risk of reactions at first exposure in infants with moderate and severe eczema. Furthermore, since children with severe eczema have the highest risk of reactions, the clinical introduction of peanut should be considered, at the latest at the age of 7\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13983","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T06:17:09Z","timestamp":1687760229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reactions to peanut at first introduction in infancy are associated with age \u22658 months and severity of eczema"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3599-6888","authenticated-orcid":false,"given":"Dirk H. J.","family":"Verhoeven","sequence":"first","affiliation":[{"name":"Department of Pediatrics Reinier de Graaf Hospital  Delft The Netherlands"},{"name":"Section of Allergology and Clinical Immunology, Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene C. E. M.","family":"Herpertz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Martini Hospital  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NoordWest Hospital Group  Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Klok","sequence":"additional","affiliation":[{"name":"Pediatrics Allergy Treatment Centre, Deventer Hospital  Deventer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne P. M.","family":"Fleuren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Elkerliek Hospital  Helmond The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Gerth\u00a0van\u00a0Wijk","sequence":"additional","affiliation":[{"name":"Section of Allergology and Clinical Immunology, Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Reinier de Graaf Hospital  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.010"},{"key":"e_1_2_11_4_1","first-page":"157","article-title":"Preventing food allergy: avoid avoidance","volume":"17","author":"Klok T","year":"2017","journal-title":"Ned Tijdschr Allergie & Astma"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030475"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-3"},{"key":"e_1_2_11_8_1","unstructured":"Dutch Guideline Database.Anaphylaxis in children 2021. Accessed October 12 2022.https:\/\/richtlijnendatabase.nl\/richtlijn\/anafylaxie_bij_kinderen\/startpagina_\u2010_anafylaxie_bij_kinderen.html"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.S3.1601"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.966"},{"key":"e_1_2_11_11_1","unstructured":"Dutch Primary Care Guidelines.Food and eating behaviour 2017. Accessed October 12 2022.https:\/\/www.jgzrichtlijnen.nl\/alle\u2010richtlijnen\/richtlijn\/voeding\u2010en\u2010eetgedrag"},{"key":"e_1_2_11_12_1","unstructured":"World Health Organization.Guideline: counselling of women to improve breastfeeding practices.2018. Accessed October 12 2022.https:\/\/apps.who.int\/iris\/rest\/bitstreams\/1176308\/retrieve"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.033"},{"key":"e_1_2_11_16_1","unstructured":"The Diet of the Dutch. Results of the Dutch National Food Consumption Survey 2012\u20102016.CTM van Rossum et al. RIVM report 2020\u20100083. Accessed October 12 2022.https:\/\/www.rivm.nl\/bibliotheek\/rapporten\/2020\u20100083.pdf"},{"key":"e_1_2_11_17_1","unstructured":"NIVEL Dutch primary care survey2018. Accessed October 12 2022.https:\/\/www.volksgezondheidenzorg.info"},{"key":"e_1_2_11_18_1","unstructured":"European Food Safety Authority (EFSA) 2019: Age to start complementary feeding of infants. Accessed October 12 2022.https:\/\/www.efsa.europa.eu\/sites\/default\/files\/Complementary_Feeding_PLS_PDF.pdf"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.03.013"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.010"},{"key":"e_1_2_11_21_1","unstructured":"British Society for Allergy & Clinical Immunology: Early Feeding Guidance 2018. Accessed October 12 2022.https:\/\/www.bsaci.org\/wp\u2010content\/uploads\/2020\/02\/pdf_Early\u2010feeding\u2010guidance\u2010for\u2010HCPs\u20102.pdf"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13496"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:01:12Z","timestamp":1692417672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/pai.13983"],"URL":"https:\/\/doi.org\/10.1111\/pai.13983","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.13983\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13983\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13983\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13983\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13983\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ei13983"}}