{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:32:15Z","timestamp":1791855135584,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000354","name":"Food Standards Agency","doi-asserted-by":"publisher","award":["TO7060"],"award-info":[{"award-number":["TO7060"]}],"id":[{"id":"10.13039\/501100000354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014364","name":"National Children's Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["12\/RC\/2272"],"award-info":[{"award-number":["12\/RC\/2272"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["15\/SP\/3091"],"award-info":[{"award-number":["15\/SP\/3091"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223047\/Z\/21\/Z"],"award-info":[{"award-number":["223047\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin barrier dysfunction is a key component of the pathogenesis of atopic dermatitis (AD). Recent research on barrier optimization to prevent AD has shown mixed results. The aim of this study was to assess the relationship between emollient bathing at 2\u2009months and the trajectory of AD in the first 2\u2009years of life in a large unselected observational birth cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints Birth Cohort study enrolled 2183 infants. Variables extracted from the database related to early skincare, skin barrier function, parental history of atopy, and AD outcomes. Statistical analysis was performed to adjust for potential confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand five hundred five children had data on AD status available at 6, 12, and 24\u2009months. Prevalence of AD was 18.6% at 6\u2009months, 15.2% at 12\u2009months, and 16.5% at 24\u2009months. Adjusted for potential confounding variables, the odds of AD at any point were higher among infants who had emollient baths at 2\u2009months (OR (95% CI): 2.41 (1.56 to 3.72), <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Following multivariable analysis, the odds of AD were higher among infants who had both emollient baths and frequent emollient application at 2\u2009months, compared with infants who had neither (OR (95% CI) at 6 months 1.74 (1.18\u20132.58), <jats:italic>p<\/jats:italic>\u2009=\u2009.038), (OR (95% CI) at 12\u2009months 2.59 (1.69\u20133.94), <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), (OR (95% CI) at 24\u2009months 1.87 (1.21\u20132.90), <jats:italic>p<\/jats:italic>\u2009=\u2009.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early emollient bathing was associated with greater development of AD by 2\u2009years of age in this population\u2010based birth cohort study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13998","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T09:16:01Z","timestamp":1689671761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early emollient bathing is associated with subsequent atopic dermatitis in an unselected birth cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-5293","authenticated-orcid":false,"given":"Cathal","family":"O'Connor","sequence":"first","affiliation":[{"name":"Paediatrics and Child Health Cork University Hospital  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Paediatrics and Child Health Cork University Hospital  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-9857","authenticated-orcid":false,"given":"Jonathan","family":"O\u2019B\u00a0Hourihane","sequence":"additional","affiliation":[{"name":"Paediatrics and Child Health Cork University Hospital  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Paediatrics and Child Health, Royal College of Physicians of Ireland  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-2044","authenticated-orcid":false,"given":"Alan D.","family":"Irvine","sequence":"additional","affiliation":[{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Dermatology Children's Health Ireland at Crumlin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0920-5291","authenticated-orcid":false,"given":"Geraldine","family":"Boylan","sequence":"additional","affiliation":[{"name":"Paediatrics and Child Health Cork University Hospital  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2201-9912","authenticated-orcid":false,"given":"Deirdre","family":"Murray","sequence":"additional","affiliation":[{"name":"Paediatrics and Child Health Cork University Hospital  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork 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