{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:34:58Z","timestamp":1791362098641,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000362","name":"Asthma UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000354","name":"Food Standards Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clustering techniques can define the heterogeneity of asthma and wheezing. Defining early\u2010life wheezing clusters and associated asthma risk could potentially inform patient management strategies. Clustering models that yield replicable cluster groups will have greater validity and clinical utility. This study sought to identify early\u2010life wheezing clusters that are translatable into clinical practice and assess their stability over time in two whole\u2010population birth cohorts established a decade apart from the same geographical location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nonparametric K\u2010means cluster analysis was performed separately on two birth cohorts from the Isle of Wight, UK; the Isle of Wight Birth Cohort (IOWBC) and Food Allergy and Intolerance Research Cohort (FAIR), using clinically defining variables in wheezing subjects in the first 3\u20134\u2009years. Associations of resulting clusters with potential early\u2010life risk factors and 10\u2010year asthma outcomes were further assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five clusters were identified in both cohorts: (1) infantile\u2010onset\u2010transient\u2010non\u2010atopic\u2010wheeze, (2) infantile\u2010onset\u2010persistent\u2010non\u2010atopic\u2010wheeze, (3) infantile\u2010onset\u2010atopic\u2010wheeze, (4) early\u2010childhood\u2010onset\u2010non\u2010atopic\u2010wheeze, and (5) early\u2010childhood\u2010onset\u2010atopic\u2010wheeze. Two atopic wheezing clusters (3 and 5) were associated with greatest early\u2010life wheeze frequency, highest wheeze persistence, and asthma prevalence at 10\u2009years. Cluster 1 was commonest but had lowest early\u2010life wheeze frequency and asthma prevalence at 10\u2009years. Cluster 2, characterized by limited atopy but recurrent infantile respiratory infections and ongoing early\u2010life wheezing, had high 10\u2010year asthma prevalence only in IOWBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early\u2010life wheeze comprises several disease clusters (two more severe and three mild\u2013moderate) with differing relationships to later childhood asthma, which can be replicated over time supporting their potential validity and clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13999","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:20:00Z","timestamp":1689726000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features and later prognosis of replicable\n                    <scp>early\u2010life<\/scp>\n                    wheeze clusters from two birth cohorts 12\u2009years apart"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-8375","authenticated-orcid":false,"given":"Suzanne Y.","family":"Ngo","sequence":"first","affiliation":[{"name":"Section of Allergy and Immunology, Department of Pediatrics University of Colorado School of Medicine, Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Division of Allergy and Clinical Immunology, Department of Medicine University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-5355","authenticated-orcid":false,"given":"Carina","family":"Venter","sequence":"additional","affiliation":[{"name":"Section of Allergy and Immunology, Department of Pediatrics University of Colorado School of Medicine, Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"William C.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Section of Allergy and Immunology, Department of Pediatrics University of Colorado School of Medicine, Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaci","family":"Picket","sequence":"additional","affiliation":[{"name":"Section of Allergy and Immunology, Department of Pediatrics University of Colorado School of Medicine, Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health University of Memphis  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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