{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:19:24Z","timestamp":1789589964659,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001355","name":"Singapore Institute for Clinical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is no consensus on the effect of timing and type of smoke exposure on early allergy development. This study aimed to determine the relationship between early eczema or food allergy\/hypersensitivity development in children by firstly investigating the effect of smoke exposure across critical development periods and secondly by analyzing effects of parental atcive or passive smoking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four databases (PubMed, Web of Science, Scopus and Embase) were searched in May 2022 and assessed by two independent reviewers. Case\u2013control, cross\u2010sectional or cohort studies reporting on smoke exposure from preconception to postnatal periods and atopic eczema, food allergy and\/or hypersensitivity outcomes by age 3\u2009years were included. The Newcastle\u2013Ottawa Scale was used to assess study quality. Random effects model was used to estimate the pooled risk ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 1689 identified records, 32 studies with nearly 190,000 subjects were included. Parental smoking during preconception, pregnancy and postnatal periods was generally not associated with the risk of eczema, food allergy and food sensitisation development by age 3\u2009years. Maternal active smoking during pregnancy was negatively associated with self\u2010reported doctor diagnosis of eczema (RR\u2009=\u20090.87, 95% CI 0.77\u20130.98;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200950.56) and maternal passive smoking during pregnancy was positively associated with clinician assessment of eczema in one study (RR\u2009=\u20091.38; 95% CI 1.06\u20131.79).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlighted the importance of in utero programming in early\u2010life allergy development. Despite the weak evidence, our results suggest pregnant women should minimise their contact with second\u2010hand smoke to prevent offspring eczema development. There is a need for greater utilisation of objective allergy assessments in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14010","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:59:39Z","timestamp":1692863979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Smoke exposure and childhood atopic eczema and food allergy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-2881","authenticated-orcid":false,"given":"Hui Xing","family":"Lau","sequence":"first","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS) Agency for Science, Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Wei","family":"Lee","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS) Agency for Science, Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qai Ven","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiong Huak","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miny","family":"Samuel","sequence":"additional","affiliation":[{"name":"Research Support Unit, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7690-3191","authenticated-orcid":false,"given":"Evelyn Xiu Ling","family":"Loo","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS) Agency for Science, Technology and Research (A*STAR)  Singapore Singapore"},{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Human Potential Translational Research Programme, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/6.8.555"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.10.037"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155501750376294"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.125"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2298\/sarh1602099r"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12406"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2020.1819793"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60928-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(00)90171-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30819-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30223-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61388-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051033"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01297.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-154"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2020.02.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.07.048"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174416000386"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00753.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900802339742"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq074"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntw299"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00490.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00543.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00545.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00759.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13045"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13156"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2011.578314"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2017.0758"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00233.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320376"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519154"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.07.002"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.800331"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.042"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12165"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb03238.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90077-f"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00834.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.01110.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-14-6"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.03.026"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.028"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01007.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14823"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh.2011.026"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107142"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd12.140377"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_269_17"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-018-0739-9"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.012468"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.826889"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.2741\/2248"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13709\/"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S54599"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200701825908"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23037"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2196"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153422"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15684"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.14010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T09:23:19Z","timestamp":1693992199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.14010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/pai.14010"],"URL":"https:\/\/doi.org\/10.1111\/pai.14010","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.14010\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14010\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14010\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14010\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14010"}}