{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:24:44Z","timestamp":1792103084744,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Broncho\u2010Vaxom (BV) is known to attenuate allergic airway inflammation and chronic bronchitis in humans, but the underlying mechanism of this gut\u2010mediated immunity remains unclear. This study investigated the effects of an oral BV on gut and systemic short\u2010chain fatty acids (SCFAs) and immune responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oral BV was administered daily for 15\u2009days prior to commencing the study in an asthma mouse model. Asthma was induced by ovalbumin (OVA) sensitization followed by a challenge with 1% OVA by inhalation. Asthmatic phenotypes, gut\u2010 and systemic\u2010 immune responses, and SCFAs in the cecum and blood were then investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Airway hyperresponsiveness, total immunoglobulin E production, and pulmonary inflammation were all significantly suppressed by BV. The interleukin\u201013 level was also suppressed, whereas TGF\u2010\u03b2 expression was increased, in the lungs of the BV\u2010treated mice. The regulatory T (Treg) cell numbers were increased in the small intestine, and the acetate level was increased in the cecum and serum after BV treatment. The levels of acetate in the cecum and serum were negatively correlated with airway hyperresponsiveness and with the eosinophil numbers in the BAL fluid of the OVA\u2010induced mice. There was a positive correlation between the acetate levels in the feces and serum and the lung expression of TGF\u2010\u03b2 in the asthma mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral BV administration appears to prevent allergic inflammation by enhancing Treg cell proliferation and acetate production in an asthmatic mouse model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.14018","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:24:13Z","timestamp":1693553053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Broncho\u2010Vaxom bacterial lysate prevents asthma via acetate enhancement in mouse model"],"prefix":"10.1111","volume":"34","author":[{"given":"Seung\u2010Hwa","family":"Lee","sequence":"first","affiliation":[{"name":"Asan Institute for Life Sciences University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Veterinary Medicine Chonnam National University  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-2113","authenticated-orcid":false,"given":"Soo\u2010Jong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center University of Ulsan College of Medicine  Seoul South 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