{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:21:17Z","timestamp":1787739677640,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dental caries and enamel defects are the main causes of poor dental health in children, with a substantial impact on their well\u2010being. Use of inhaled asthma medication is a suspected risk factor, but there is a lack of prospective studies investigating this and other prenatal and early life risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Copenhagen Prospective Studies on Asthma in Childhood 2010 mother\u2013child cohort (COPSAC<jats:sub>2010<\/jats:sub>) consists of 700 women who were recruited at 24\u2009weeks of pregnancy. 588 of their children participated in a dental examination at 6\u2009years of age (84%) at the COPSAC<jats:sub>2010<\/jats:sub> research unit. Caries was defined as decayed, missing, or filled surfaces. Enamel defect was defined as demarcated opacity, post\u2010eruptive enamel breakdown, and\/or atypical restoration on at least one molar. Caries and enamel defects were assessed in both deciduous and permanent dentitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no associations between inhaled corticosteroids or \u03b2<jats:sub>2<\/jats:sub>\u2010agonists or asthma symptoms in early childhood and the risk of caries or enamel defects by 6\u2009years of age. Furthermore, we found no strong pre\u2010, peri\u2010, or postnatal risk factors for dental diseases at 6\u2009years, except from nominally significant associations between antibiotic use in pregnancy (OR\u2009=\u20091.25, [1.01\u20131.54]), maternal education level (OR\u2009=\u20091.57, [1.01\u20132.45]), having a dog at home (OR\u2009=\u20090.50, [0.27\u20130.93]), and risk of enamel defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of inhaled corticosteroids, \u03b2<jats:sub>2<\/jats:sub>\u2010agonists, or asthma symptoms in the first 6\u2009years of life were not associated with the development of caries or enamel defects. This finding is reassuring for parents and physicians prescribing asthma medication for young children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.14026","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:18:55Z","timestamp":1697073535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Asthma medication and risk of dental diseases in children \u2013 A prospective cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-0418","authenticated-orcid":false,"given":"Pia Elisabeth","family":"N\u00f8rrisgaard","sequence":"first","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) Copenhagen University Hospital \u2010 Herlev and Gentofte  Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte","family":"Haubek","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5827-0885","authenticated-orcid":false,"given":"Ann\u2010Marie Malby","family":"Schoos","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) Copenhagen University Hospital \u2010 Herlev and Gentofte  Gentofte Denmark"},{"name":"Department of Peadiatrics Slagelse Sygehus  Slagelse Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"K\u00fchnisch","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-6243","authenticated-orcid":false,"given":"Bo L.","family":"Chawes","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) Copenhagen University Hospital \u2010 Herlev and Gentofte  Gentofte Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-9769","authenticated-orcid":false,"given":"Jakob","family":"Stokholm","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) Copenhagen University Hospital \u2010 Herlev and Gentofte  Gentofte Denmark"},{"name":"Department of Peadiatrics Slagelse Sygehus  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-7592","authenticated-orcid":false,"given":"Hans","family":"Bisgaard","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) Copenhagen University Hospital \u2010 Herlev and Gentofte  Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"B\u00f8nnelykke","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) Copenhagen University Hospital \u2010 Herlev and Gentofte  Gentofte Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"issue":"7","key":"e_1_2_12_2_1","first-page":"403","article-title":"Is caries associated with negative impact on oral health\u2010related quality of life of pre\u2010school children? 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