{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:59:35Z","timestamp":1792119575565,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pru p 7 has been reported as a major allergen in peach allergy, associated with severe clinical symptoms and related to IgE sensitisation to cypress pollen. The main objective of this study was to prospectively evaluate the frequency of sensitisation to Pru p 7 and its clinical relevance amongst pediatric patients with peach allergy in Madrid (Spain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a history of IgE\u2010mediated symptoms (oral allergy syndrome, urticaria\/angioedema, rhinoconjunctivitis\/asthma, gastrointestinal symptoms, or anaphylaxis) occurring within 2\u2009h after peach intake or contact were prospectively recruited from February 2020 to September 2021. Skin tests, sIgE by ImmunoCAP\u00ae (Pru p 1, Pru p 3, Pru p 4, Pru p 7, and <jats:italic>Cupressus arizonica<\/jats:italic>) and oral food challenge (OFC) were performed. The study was approved by the local Ethics Committee (PI\u20104513).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two patients were included (53.3% male); median age, 10 (IQR 6.0\u201314.75) years. Seventy\u2010four (80.4%) patients had a reaction after ingestion of fresh peach (25.0% from peel, 23.9% from pulp, and 44.6% from both). Fifteen (16.3%) patients were sensitised to Pru p 7. Upper airway symptoms, anaphylaxis, and grade 2 reactions were statistically more frequent in patients sensitised to Pru p 7. Seven (7.9%) patients presented with exercise as a cofactor, four of whom were sensitised to Pru p 7 (<jats:italic>p<\/jats:italic>\u2009=\u2009.001). Patients sensitised to Pru p 7 were significantly more likely to have a positive OFC result than patients who were not (<jats:italic>p<\/jats:italic>\u2009=\u2009.008). Four patients who reacted to peach at OFC were sensitised to Pru p 7. Specific IgE against <jats:italic>Cupressus arizonica<\/jats:italic> pollen was positive in 25 (62.5%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pru p 7 sensitisation was observed in 16.3% of our population and was related to severe reactions, upper airway symptoms, anaphylaxis, and the presence of an eliciting cofactor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.14030","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:30:36Z","timestamp":1695641436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sensitisation to peach allergen Pru p 7 is associated with severe clinical symptoms in a Spanish population"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3735-6129","authenticated-orcid":false,"given":"Francisca","family":"V\u00edlchez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Allergy, Institute for Health Research (IdiPAZ) La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rodr\u00edguez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Allergy, Institute for Health Research (IdiPAZ) La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-6267","authenticated-orcid":false,"given":"Carmen","family":"G\u00f3mez\u2010Traseira","sequence":"additional","affiliation":[{"name":"Department of Allergy, Institute for Health Research (IdiPAZ) La Paz University Hospital  Madrid 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