{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:30:20Z","timestamp":1781184620217,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R16\u2010A1694"],"award-info":[{"award-number":["R16\u2010A1694"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["903516"],"award-info":[{"award-number":["903516"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["0603\u201000280B"],"award-info":[{"award-number":["0603\u201000280B"]}],"id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202006790042"],"award-info":[{"award-number":["202006790042"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood eosinophil count is a well\u2010established biomarker of atopic diseases in older children and adults. However, its predictive role for atopic diseases in preschool children is not well established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between blood eosinophil count in children and development of atopic diseases up to age 6\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We investigated blood eosinophil count at age 18\u2009months and 6\u2009years in relation to recurrent wheeze\/asthma, atopic dermatitis, allergic rhinitis, and allergic sensitization during the first 6\u2009years of life in the two Copenhagen Prospective Studies on Asthma in Childhood cohorts (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091111). Blood eosinophil count was investigated in association with remission of existing atopic disease, current atopic disease, and later development of atopic disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Blood eosinophil count at 18\u2009months was not associated with current wheezing\/asthma or atopic dermatitis, while blood eosinophil count at age 6\u2009years was associated with increased occurrence of current wheezing\/asthma (OR\u2009=\u20091.1; 1.04\u20131.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0005), atopic dermatitis (OR\u2009=\u20091.06; 1.01\u20131.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02), and allergic rhinitis (OR\u2009=\u20091.11; 1.05\u20131.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0002). Blood eosinophil count at 18\u2009months did not predict persistence or development of recurrent wheeze\/asthma or atopic dermatitis at age 6\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Blood eosinophil count at 18\u2009months was not associated with current wheezing\/asthma or atopic dermatitis and did not predict persistence or development of disease. This implies a limited clinical role of blood eosinophil levels in early\u2010life atopic disease and questions the clinical value of blood eosinophil counts measured in toddlers as a predictive biomarker for subsequent atopic disease in early childhood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14050","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T18:50:42Z","timestamp":1701111042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Limited clinical role of blood eosinophil levels in early life atopic disease: A mother\u2013child cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-6555","authenticated-orcid":false,"given":"Signe Kjeldgaard","family":"Jensen","sequence":"first","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Department of Pediatrics, Herlev and Gentofte Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1663-7137","authenticated-orcid":false,"given":"Mathias Elsner","family":"Melgaard","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Department of Pediatrics, Herlev and Gentofte Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-5373","authenticated-orcid":false,"given":"Casper\u2010Emil Tingskov","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Department of Pediatrics, Herlev and Gentofte Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-7946","authenticated-orcid":false,"given":"Luo","family":"Yang","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Department of Pediatrics, Herlev and Gentofte Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3604-2602","authenticated-orcid":false,"given":"Nilo","family":"Vahman","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Department of Pediatrics, Herlev and Gentofte Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-1743","authenticated-orcid":false,"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of 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