{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:50:38Z","timestamp":1789753838037,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012371","name":"Faculty of Science and Engineering, University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Component\u2010resolved diagnosis (CRD) has been decisive in exploring the mechanisms of IgE sensitization, but the predictive ability to detect asthma has not been addressed. We aim to develop and evaluate the performance of a personalized predictive algorithm for asthma that integrates information on allergic sensitization using CRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One thousand one hundred one twenty\u2010five\n                      <jats:bold>c<\/jats:bold>\n                      hildren from the Generation XXI birth cohort were randomly selected to perform a screening test for allergic sensitization and a subsample was characterized using CRD against 112 allergen components. Allergen components were analyzed using volcano plots and partial least squares (PLS) analysis. Logistic regression was performed to assess the associations between the obtained latent components (LC) and allergic outcomes (asthma, rhinitis, eczema) including other potential predictors used in previous asthma risk scores. The accuracy of the model in predicting asthma was assessed using Receiver Operating Characteristic (ROC) curve statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the PLS, the first LC was positively associated with asthma, rhinitis, and eczema. This LC was mainly driven by positive weights for Der p 1\/2\/23, Der f 1\/2, and Fel d 1. The main components in the second LC were pollen and food allergens. History of early wheezing and parental allergy were included in the predictive model and the area under the curve improved to 0.82.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first approach to improve the clinical applicability of CRD by combining CRD and clinical data to predict asthma at 13\u2009years. Sensitization to distinct allergen molecules seems relevant to improve the accuracy of asthma prediction models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14056","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T10:21:35Z","timestamp":1702203695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Component\u2010resolved diagnosis in childhood and prediction of asthma in early adolescence: A birth cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4959-0975","authenticated-orcid":false,"given":"Mariana","family":"Farraia","sequence":"first","affiliation":[{"name":"EPIUnit \u2013 Instituto de Sa\u00fade P\u00fablica Universidade do Porto  Porto Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR) Universidade do Porto  Porto Portugal"},{"name":"Department of Pathology, Faculty of Medicine, Basic and Clinical Immunology Unit University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-8408","authenticated-orcid":false,"given":"Francisca Castro","family":"Mendes","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Instituto de Sa\u00fade P\u00fablica Universidade do Porto  Porto Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR) Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-8066","authenticated-orcid":false,"given":"Oksana","family":"Sokhatska","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Basic and Clinical Immunology Unit University of Porto  Porto 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