{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:55:50Z","timestamp":1781279750889,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mites are ubiquitous aeroallergens found worldwide. Elucidating individual mite allergen sensitization patterns provides critical insights for managing allergic diseases. This study aimed to investigate molecular allergen (MA) sensitization patterns across different age groups and explore cluster relationships among mite\u2010sensitized children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 76 children who exhibited sensitization to at least one of the 17 distinct mite MAs through microarray testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dermatophagoides farinae exhibited a slightly higher prevalence of sensitization compared with Dermatophagoides pteronyssinus. Der p 1\/2 and Der f 1\/2 demonstrated an almost 40% sensitization rate, while Der p 10\/Blo t 10, Der p 20, Der p 23, and Gly d 2\/Lep d 2 displayed an approximately 20% sensitization rate. Sensitization levels and ratios increased significantly with age for Der p 23 but showed numerical rises for other MAs, except for Der p 10\/Blo t 10. The presence of various types of atopic diseases had only a minimal impact on sensitization profiles. Strong correlations emerged between Der f 2 and Der p 2, Der p 10 and Blo t 10, Der p 21 and Blo t 5, as well as Gly d 2 and Lep d 2. Hierarchical cluster analysis substantiated these relationships. Der p 10 and its homolog Blo t 10\u2010sensitive patients (15\/76) were mostly seen as mono sensitization(12\/15). Ten patients exhibited monosensitization to Der p 20, suggesting a possible association with scabies infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children, mite sensitization diversity and levels increased with age. The presence of significant correlations\/cluster relationships among these sensitizations underscores homologies among specific MAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14093","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T10:57:21Z","timestamp":1708426641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mite allergen sensitization patterns in Turkish children: Age\u2010related changes and molecular correlations"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-8014","authenticated-orcid":false,"given":"Sevda","family":"Tuten\u00a0Dal","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara 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