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Interventions aimed at correcting skin barrier dysfunction have been explored in recent decades as a distinct or complementary mean to prevent allergic sensitization through the skin and subsequent development of FA. Studies assessing the application of emollient from birth have yielded conflicting results, and meta\u2010analyses have demonstrated either no effect or only a slight positive effect on FA prevention. However, a careful review of the clinical trials reveals that different emollients were used, which may have explained some of the discrepancies between study results. Emollient application protocols also varied widely between studies. While firm conclusions cannot be drawn with regard to their overall efficacy at preventing FA, the available data provide valuable insight into the characteristics that could be associated with a more effective intervention. Namely, successful trials tended to use emollients with an acidic pH of 5.5, applied over the entire body, and combined with topical corticosteroids in affected areas. Consensus on the optimal strategy to restore skin barrier function could help improve the homogeneity and clinical relevance of future trials on this topic. In the meantime, clinicians should avoid products associated with worse outcomes.<\/jats:p>","DOI":"10.1111\/pai.14130","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T02:58:35Z","timestamp":1714618715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Skin\u2010centered strategies in food allergy prevention"],"prefix":"10.1111","volume":"35","author":[{"given":"Camille","family":"Braun","sequence":"first","affiliation":[{"name":"Section of Allergy and Clinical Immunology, Department of Pediatrics Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Quebec Canada"},{"name":"Department of Pediatrics, Pneumology, Allergy, Cystic Fibrosis H\u00f4pital Femme M\u00e8re Enfant  Bron France"},{"name":"Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR 5308, Universit\u00e9 Lyon 1  Lyon 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