{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:58:38Z","timestamp":1791979118768,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010769","name":"Axencia Galega de Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The morbidity burden of respiratory syncytial virus (RSV) in infants extends beyond hospitalization. Defining the RSV burden before implementing prophylaxis programs is essential for evaluating any potential impact on short\u2010 to mid\u2010term morbidity and the utilization of primary healthcare (PHC) and emergency services (ES). We established this reference data using a population\u2010based cohort approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Infants hospitalized for RSV from January 2016 to March 2023 were matched with non\u2010hospitalized ones based on birthdate and sex. We defined the exposure as severe RSV hospitalization. The main study outcomes were as follows: (1) PHC and ES visits for RSV, categorized using the International Classification of Primary Care codes, (2) prescriptions for respiratory airway obstructive disease, and (3) antibacterial prescriptions. Participants were followed up from 30\u2009days before hospitalization for severe RSV until the outcome occurrence or end of the study. Adjusted incidence rate ratios (IRRs) of the outcomes along with their 95% confidence intervals (CI) were estimated using Poisson regression models. Stratified analyses by type of PHC visit (nurse, pediatrician, or pharmacy) and follow\u2010up period were undertaken. We defined mid\u2010term outcomes as those taking place up to 24\u2009months of follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 6626 children (3313 RSV\u2010hospitalized; 3313 non\u2010hospitalized) with a median follow\u2010up of 53.7\u2009months (IQR\u2009=\u200927.9, 69.4). After a 3\u2010month follow\u2010up, severe RSV was associated with a considerable increase in PHC visits for wheezing\/asthma (IRR\u2009=\u20094.31, 95% CI: 3.84\u20134.84), lower respiratory infections (IRR\u2009=\u20094.91, 95% CI: 4.34\u20135.58), and bronchiolitis (IRR\u2009=\u20094.68, 95% CI: 2.93\u20137.65). Severe RSV was also associated with more PHC visits for the pediatrician (IRR\u2009=\u20092.00, 95% CI: 1.96\u20132.05), nurse (IRR\u2009=\u20091.89, 95% CI: 1.75\u20131.92), hospital emergency (IRR\u2009=\u20092.39, 95% CI: 2.17\u20132.63), primary healthcare emergency (IRR: 1.54, 95% CI: 1.31\u20131.82), as well as with important increase in prescriptions for obstructive airway diseases (IRR\u2009=\u20095.98, 95% CI: 5.43\u20136.60) and antibacterials (IRR\u2009=\u20094.02, 95% CI: 3.38\u20134.81). All findings remained substantial until 2\u2009years of post\u2010infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Severe RSV infection in infants significantly increases short\u2010 to mid\u2010term respiratory morbidity leading to an escalation in healthcare utilization (PHC\/ES attendance) and medication prescriptions for up to 2\u2009years afterward. Our approach could be useful in assessing the impact and cost\u2010effectiveness of RSV prevention programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14131","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T07:38:44Z","timestamp":1714721924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Short\u2010 and mid\u2010term morbidity and primary\u2010care burden due to infant respiratory syncytial virus infection: A Spanish 6\u2010year population\u2010based longitudinal study"],"prefix":"10.1111","volume":"35","author":[{"given":"Sonia","family":"Ares\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"Genetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP) Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS)  Santiago de Compostela Galicia Spain"},{"name":"WHO Collaborating Centre for Vaccine Safety  Santiago de Compostela 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