{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:02:59Z","timestamp":1784026979036,"version":"3.55.0"},"reference-count":102,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009228","name":"Region \u00d6rebro l\u00e4n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta\u2010analysis guidelines. The inclusion criteria were original research articles or case reports written in English describing a human placental change in relation to disease occurring in offspring during childhood. The MEDLINE and EMBASE databases were searched for eligible studies. Risk of bias (RoB) was assessed using the ROBINS\u2010I tool. The results were pooled both in a narrative way and by a meta\u2010analysis. Nineteen studies were included (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912,997 participants). All studies had an overall serious RoB, and publication bias could not be completely ruled out. However, five studies showed that histological chorioamnionitis in preterm\u2010born children was associated with asthma\u2010related problems (pooled odds ratio\u2009=\u20093.25 (95% confidence interval\u2009=\u20092.22\u20134.75)). In term\u2010born children, a large placenta (\u2265750\u2009g) increased the risk of being prescribed anti\u2010asthma medications during the first year of life. Placental histone acetylation, DNA methylation, and gene expression differences were found to be associated with different atopic disorders in term\u2010born children. There is some evidence supporting the idea that the placenta can mediate an increased risk of atopic disorders in children. However, further studies are needed to validate the findings, properly control for confounders, and examine potential mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/pai.14141","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T01:14:48Z","timestamp":1716340488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Childhood atopic disorders in relation to placental changes\u2014A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"given":"Zaki","family":"Bakoyan","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Unit of Integrative Epidemiology, Institute of Environmental Medicine Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R.","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Science Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Patriksson","family":"Karlsson","sequence":"additional","affiliation":[{"name":"University Health Care Research Center, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-4913","authenticated-orcid":false,"given":"Maria","family":"Lodefalk","sequence":"additional","affiliation":[{"name":"University Health Care Research Center, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Department of Pediatrics, School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01344-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02494.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052885"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.09.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90049-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6761.1111"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318045bedb"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12408"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443961"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328357a3bc"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2871"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124776"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.044"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12762"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01346.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2017.9.3.200"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2196"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics9120338"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02831.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14542-4"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12350"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0066"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.03.039"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/985646"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00588"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0773"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060339"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.030"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2015"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.013029"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.55.4.571b"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030435"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599149"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.02.006"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"issue":"5","key":"e_1_2_11_38_1","first-page":"645","article-title":"The effect of smoking in pregnancy on early placental morphology","volume":"79","author":"Jauniaux E","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.07.016"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2023.108409"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.06.038"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-549720200004"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2021.1977237"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2016.1249284"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-021-00633-3"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.18332\/tid\/146905"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0427"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01524.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13312"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7304.101"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2014.07.002"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2018.1493603"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02572-9"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201507-411OC"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.030"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.2350\/09-06-0659-OA.1"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1315257"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14618"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12990"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.020"},{"issue":"1","key":"e_1_2_11_61_1","first-page":"60","article-title":"Prenatal maternal anxiety promotes atopic dermatitis in offspring via placental DNA methylation changes","volume":"41","author":"Kim HB","year":"2023","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.09.008"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2020.02.009"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa057"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201610-2141OC"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01161-y"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.23937\/2378-3516\/1410033"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025390420122"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25592"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01633-0"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31558-z"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6010004"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.238"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.531543"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0582-6"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081193"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6746.259"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040534"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165535"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13498"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939709003856"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2004.01.008"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603252"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303243"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.10.010"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.023"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.39106"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-01047-1"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1093990"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000349"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.007"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.92.BJR-2019-0172.R1"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.558981"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-015-0159-x"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.011"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235545"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.07.023"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14281"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00794.x"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12652"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070784"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2020.1814504"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.14141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T09:08:33Z","timestamp":1722416913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.14141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":102,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/pai.14141"],"URL":"https:\/\/doi.org\/10.1111\/pai.14141","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.14141\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14141\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14141\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14141\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14141\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14141\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14141\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14141\/v3\/response1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14141"}}