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Our study investigates the correlation between inadequate asthma control, exhaled nitric oxide (FENO) levels, and anxiety and depression among pediatric asthma patients with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective case\u2013control study enrolled 520 asthmatic children (8\u201315\u2009years), including 336 patients diagnosed with COVID\u201019 after rapid antigen testing at home and 184 age\u2010matched asthmatic patients without COVID\u201019 infection. FENO and spirometry were performed 1\u2009month after COVID\u201019 infection. Scores for Child Anxiety\u2010Related Disorders (SCARED) and depression screen derived from Patient Health Questionnaire\u20109 (PHQ\u20109) to assess their mental health status. Childhood asthma control test (C\u2010ACT), FENO levels, and spirometry were correlated with the SCARED and PHQ\u20109 questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SCARED subscales, including generalized anxiety disorder, social anxiety disorder, school avoidance, and depression scores from PHQ\u20109, exhibited a significant increase in asthmatic patients diagnosed with COVID\u201019 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Among asthmatic children with SARS\u2010CoV\u20102 infection, the poor asthma control group exhibited the highest SCARED and PHQ\u20109 measurements (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Multiple linear regression analysis indicated that reduced C\u2010ACT scores and elevated FENO levels in asthmatic children with COVID\u201019 were significant risk factors for both anxiety and depression scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Lower C\u2010ACT scales were associated with high scores of SCARED (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.471) and PHQ\u20109 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.329) in asthmatic children (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study emphasizes the need for healthcare professionals to closely monitor asthma control in asthmatic children to prevent heightened risks of depression and anxiety during the ongoing COVID\u201019 pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.14168","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T10:21:18Z","timestamp":1718360478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Asthma control associated with anxiety and depression in asthmatic children following post\u2010acute COVID\u201019"],"prefix":"10.1111","volume":"35","author":[{"given":"Tung\u2010Ming","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Changhua Christian Children's Hospital  Changhua Taiwan"},{"name":"Child Development Center Changhua Christian Children's Hospital  Changhua Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Child Development Center Changhua Christian Children's Hospital  Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuender D.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mackay Memorial Hospital  New Taipei City Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4540-9822","authenticated-orcid":false,"given":"Jiu\u2010Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Allergy, Immunology, and Microbiome (A.I.M.) 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