{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:38:24Z","timestamp":1790401104091,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is frequently associated with asthma and allergic rhinitis (AR). Dupilumab is an effective treatment for pediatric AD, although the effect on atopic comorbidities in pediatric AD patients is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the prevalence of asthma and AR in pediatric AD patients starting dupilumab treatment and to evaluate the effect of dupilumab on these comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included pediatric AD patients (aged 3\u201317\u2009years) treated with dupilumab between 2019 and 2023. Patients were screened at baseline by a pulmonologist for the presence of asthma and AR. Screening included evaluation of medical history and current symptoms, spirometry (including Forced Expiratory Volume in 1\u2009s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      )), Fractional exhaled Nitric Oxide (FeNO), and measurement of aeroallergen\u2010specific IgE levels. In patients diagnosed with comorbid asthma and\/or AR, measurements were repeated at weeks 16 and 52. Spirometry measurements, FeNO, and aeroallergen\u2010specific IgE levels during treatment were analyzed using a covariance pattern model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010four patients were included. Asthma was diagnosed in 50 patients (59.5%) and AR in 72 patients (85.7%). Baseline FeNO levels were elevated in both patients with (29.0\u2009ppb (95% CI 22.0\u201354.0)) and without asthma (26.0\u2009ppb (95% CI 22.0\u201330.0)). During treatment, FeNO levels decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and FEV\n                      <jats:sub>1<\/jats:sub>\n                      scores increased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) in patients with asthma. In patients with asthma and\/or AR, all aeroallergen\u2010specific IgE levels decreased between 61.3% and 89.1% at 52\u2009weeks of treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One year of dupilumab treatment, primarily indicated for AD, resulted in a significant improvement in comorbid asthma and a profound decrease in aeroallergen\u2010specific IgE levels in patients with asthma and\/or AR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14178","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T06:53:04Z","timestamp":1718866384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of dupilumab on asthma and aeroallergen sensitization in pediatric atopic dermatitis patients: Results of the\n                    <scp>BioDay<\/scp>\n                    registry"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-8986","authenticated-orcid":false,"given":"Lisa P.","family":"van der Rijst","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht University  Utrecht The Netherlands"},{"name":"Department of Dermatology and Allergology, National Expertise Center for Atopic Dermatitis University Medical Center Utrecht, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin M.","family":"de Winter\u2010de Groot","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas P. A.","family":"Zuithoff","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein S.","family":"de Bruin\u2010Weller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, National Expertise Center for Atopic Dermatitis University Medical Center Utrecht, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht University  Utrecht The Netherlands"},{"name":"Department of Dermatology and Allergology, National Expertise Center for Atopic Dermatitis University Medical Center Utrecht, Utrecht University  Utrecht The 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