{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:54:53Z","timestamp":1794002093053,"version":"4.8.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While food allergy (FA) has been increasingly recognized as a growing public health burden worldwide, epidemiological studies on FA in Japan are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a noninterventional, observational study using the administrative claims data from 2010 to 2019 (10\u2009years). Patients with physician\u2010diagnosed FA in Japan (prevalent cohort) were divided into high\u2010risk or low\u2010risk cohorts using adrenaline prescription. The high\u2010risk cohort was further divided into anaphylaxis or nonanaphylaxis cohort based on the occurrence of anaphylaxis or a serious allergic reaction (SAR) during 1\u2009year after adrenaline prescription. The primary objective was to examine yearly prevalence of FA. The secondary objectives were to describe demographics\/clinical characteristics and healthcare resource utilization (HCRU), to evaluate the number of occurrences of anaphylaxis\/SAR in the high\u2010risk cohort, and the impact of anaphylaxis\/SAR on HCRU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall standardized prevalence rate was 0.325% (95% confidence interval [CI], 0.311\u20130.339) in 2010 and 0.797% (95% CI, 0.790\u20130.804) in 2019 and predominant in patients age &lt;6\u2009years (preschool; 3.377% [95% CI, 3.229\u20133.525] in 2010 and 5.726% [95% CI, 5.663\u20135.789] in 2019). Majority of FA patients (&gt;80%) were children\/adolescent throughout the 10\u2009years. While high\u2010risk cohort was a relatively minor population (8.5% in the prevalent cohort in 2019), the occurrence of anaphylaxis\/SAR in the high\u2010risk cohort was 227,690\/100,000 patient\u2010years. Multivariate analysis showed a significant increase in HCRU variables in the anaphylaxis versus nonanaphylaxis cohort (e.g., 2.08 [95% CI, 2.05\u20132.11] times more FA\u2010related outpatient visits).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prevalence of FA increased in a statistically significant way from 2010 to 2019; 1.7\u2010fold increase was observed in patients &lt;6\u2009years old. Patients in the high\u2010risk cohort appear to have suffered from frequent anaphylaxis\/SAR, highlighting an unmet medical need for FA patients at \u201chigh\u2010risk,\u201d considering the unavailability of approved medications to prevent anaphylaxis\/SAR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14192","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T07:38:24Z","timestamp":1721029104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of food allergy increased 1.7 times in the past 10\u2009years among Japanese patients below 6\u2009years of age"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-3211","authenticated-orcid":false,"given":"Hajime","family":"Yoshisue","sequence":"first","affiliation":[{"name":"Novartis Pharma K.K.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Homma","sequence":"additional","affiliation":[{"name":"JMDC Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Ito","sequence":"additional","affiliation":[{"name":"Novartis Pharma K.K.  Tokyo Japan"},{"name":"JMDC Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-558X","authenticated-orcid":false,"given":"Motohiro","family":"Ebisawa","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology National Hospital Organization Sagamihara National Hospital  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15092043"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.09.003"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12908"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0204"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.5630"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2017.02.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.936"},{"key":"e_1_2_13_9_1","unstructured":"Statistics of Japan.https:\/\/www.e\u2010stat.go.jp\/en\/stat\u2010search\/files?page=1&layout=datalist&toukei=00200524&tstat=000000090001&cycle=7&tclass1=000001011679&tclass2val=0. 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