{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:54:05Z","timestamp":1792547645616,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Sublingual immunotherapy (SLIT) for perennial allergic rhinitis (AR) has not been extensively studied in preschoolers. We investigated the efficacy and safety of house dust mite (HDM) SLIT\u2010tablet for children aged 1\u20134\u2009years.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Children aged 1\u20134\u2009years with AR were divided into SLIT (\n n<\/jats:italic>\n \u2009=\u200922) and control (\n n<\/jats:italic>\n \u2009=\u200912) groups based on their guardians' preferences. The SLIT group received a daily dose of 10,000 JAU of HDM SLIT\u2010tablet for 12\u2009months, whereas the control group received symptomatic treatment only.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The baseline median age was 41 and 34\u2009months in the SLIT and control groups, respectively, and the median AR symptom score was 4 for both groups. Compared with baseline, the AR symptom score had decreased significantly in the SLIT group after 12\u2009months (score: 3,\n p<\/jats:italic>\n \u2009=\u2009.002), whereas it tended to increase in the control group (score: 6,\n p<\/jats:italic>\n \u2009=\u2009.08). Adverse reactions to SLIT were mild and occurred in eight patients (36%). In the SLIT group,\n Dermatophagoides<\/jats:italic>\n (\n D.<\/jats:italic>\n )\n farinae<\/jats:italic>\n \u2010specific IgE (sIgE) levels increased during the first 6\u2009months and decreased to baseline levels at 12\u2009months. In the control group,\n D. farinae<\/jats:italic>\n \u2010sIgE levels had increased significantly at 12\u2009months compared to baseline (\n p<\/jats:italic>\n \u2009=\u2009.01).\n D. farinae\u2010<\/jats:italic>\n specific IgG\n 4<\/jats:sub>\n and HDM IgE\u2010blocking factor levels were significantly increased at 12\u2009months compared to baseline in the SLIT group only (\n p<\/jats:italic>\n \u2009<\u2009.001). A lower wheezing frequency was seen in the SLIT group (0.3%) compared to the control group (0.7%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This pilot study demonstrated the efficacy, safety, and immunomodulatory effects of HDM SLIT\u2010tablet in preschoolers with AR.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.14203","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T05:48:42Z","timestamp":1721800122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of sublingual immunotherapy using house dust mite tablet for 1\u20134\u2009years old children with perennial allergic rhinitis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-6453","authenticated-orcid":false,"given":"Koki","family":"Sasamoto","sequence":"first","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Minami\u2010ku Sagamihara Japan"},{"name":"Department of Pediatrics Toho University Ohashi Medical Center Meguro\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-9044","authenticated-orcid":false,"given":"Ken\u2010ichi","family":"Nagakura","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Minami\u2010ku Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-5421","authenticated-orcid":false,"given":"Tomoyuki","family":"Asaumi","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Minami\u2010ku Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-8135","authenticated-orcid":false,"given":"Naoko","family":"Fusayasu","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Minami\u2010ku Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5104-6952","authenticated-orcid":false,"given":"Katsuyo","family":"Ohashi\u2010Doi","sequence":"additional","affiliation":[{"name":"Torii Pharmaceutical Co., Ltd. Chuo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-744X","authenticated-orcid":false,"given":"Noriyuki","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Minami\u2010ku Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-0759","authenticated-orcid":false,"given":"Sakura","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Minami\u2010ku Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-558X","authenticated-orcid":false,"given":"Motohiro","family":"Ebisawa","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical 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