{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:23:02Z","timestamp":1782973382958,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL109977"],"award-info":[{"award-number":["R01 HL109977"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL132338"],"award-info":[{"award-number":["R01 HL132338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 HL150312"],"award-info":[{"award-number":["K24 HL150312"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3\/UH3 OD023271"],"award-info":[{"award-number":["UG3\/UH3 OD023271"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 ES023515"],"award-info":[{"award-number":["P30 ES023515"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We investigated the individual and interaction effects of maternal plasma \ud835\udec2\u2010 and \u03d2\u2010tocopherol levels (vitamin E isomers) on child asthma and wheeze at age 8\u20139.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Mother\u2013child dyads were enrolled between 2006 and 2011 into the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) prenatal cohort. Maternal second\u2010trimester samples were analyzed for tocopherol and lipid concentrations. We assessed child asthma\/wheeze using the International Study of Asthma and Allergies in Childhood (ISAAC) and other self\u2010reported Ent wheeze. In multivariable logistic regression analyses, we assessed associations between vitamin E isomers and child asthma\/wheeze outcomes (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009847 mother\u2013child dyads) and tested for prespecified interaction terms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median cholesterol\u2010corrected tocopherol levels (interquartile range (IQR)) were 5.0 (4.3\u20135.7) and 0.8 (0.7\u20130.9) (umol\/mmol) for \ud835\udec2\u2010 and \u03d2\u2010tocopherol, respectively. Associations between \ud835\udec2\u2010tocopherol and asthma outcome variables were inverse but not statistically significant. In contrast, for \u03d2\u2010tocopherol, associations were in the positive direction, but also nonsignificant. Interactions analysis between tocopherols did not reach statistical significance for any outcome. Among children of women with a history of asthma, the likelihood of ever asthma in the child appears to be decreasing with increasing maternal \ud835\udec2\u2010tocopherol levels, whereas this trend was not observed among those without a history of asthma (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010interaction\u2009=\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed no associations for prenatal \ud835\udec2\u2010 or \u03d2\u2010tocopherol concentrations with child asthma\/wheeze. We detected some evidence of effect modification by maternal asthma history in associations between \ud835\udec2\u2010tocopherol and child asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14208","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T07:48:29Z","timestamp":1722498509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of prenatal vitamin E levels with child asthma and wheeze"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5942-3161","authenticated-orcid":false,"given":"Terryl J.","family":"Hartman","sequence":"first","affiliation":[{"name":"Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tebeb","family":"Gebretsadik","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-5514","authenticated-orcid":false,"given":"Margaret A.","family":"Adgent","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Health Policy Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshae","family":"Nickelberry","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Tennessee Health Sciences Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecelia S.","family":"Alcala","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Environmental Medicine &amp; Climate Science Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Environmental Medicine &amp; Climate Science Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  San Francisco California USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja Z.","family":"LeWinn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind J.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Public Health and Environmental Medicine and Climate Science Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-1374","authenticated-orcid":false,"given":"Kecia N.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Environmental Medicine &amp; Climate Science Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"National Health Interview Survey","year":"2019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.01.026"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0501-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.006254"},{"key":"e_1_2_12_6_1","unstructured":"VitaminE.Dietary reference intakes for Vitamin C Vitamin E selenium and carotenoids.Food and Nutrition Board Institute of Medicine."},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135510"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2016.1184090"},{"key":"e_1_2_12_9_1","volume-title":"Nutritional Epidemiology","author":"Willet W","year":"2013"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.019"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.10.045"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487388"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5051511"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7249\/RR1336"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.10.039"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26342"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.04.034"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456328602300505"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.1.44"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.6.943"},{"key":"e_1_2_12_21_1","unstructured":"IOM.Dietary Reference Intakes for Vitamin C Vitamin E Selenium and Carotenoids.2000."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.016"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00074608"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.14208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T08:59:45Z","timestamp":1724921985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.14208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/pai.14208"],"URL":"https:\/\/doi.org\/10.1111\/pai.14208","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.14208\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14208\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14208\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14208\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.14208\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14208"}}