{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:16:39Z","timestamp":1774314999084,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Asthma is the most common chronic respiratory disease in childhood.\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      sensitivity may be involved in the pathogenesis of asthma by leading to different clinical presentations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the demographic, clinical, laboratory, and radiological characteristics of\n                      <jats:italic>A<\/jats:italic>\n                      .\n                      <jats:italic>fumigatus<\/jats:italic>\n                      sensitivity in childhood asthma and identify associated risk factors and diagnostic parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 259 children with asthma were included in the study, 7 (2.7%) with allergic bronchopulmonary aspergillosis (ABPA), 84 (32.4%) with\n                      <jats:italic>A<\/jats:italic>\n                      .\n                      <jats:italic>fumigatus<\/jats:italic>\n                      \u2010sensitized asthma (Af\u2010SA), and 168 (64.9%) with\n                      <jats:italic>A<\/jats:italic>\n                      .\n                      <jats:italic>fumigatus<\/jats:italic>\n                      \u2010unsensitized asthma (Af\u2010UA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      sensitivity was associated with early asthma onset and longer asthma duration. Total IgE level and asthma severity are highest in ABPA and higher in Af\u2010SA. Absolute eosinophil count was higher, and FEV1 was lower in Af\u2010SA and ABPA.\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      was associated with greater odds of being male (odds ratio [OR], 2.45), having atopic dermatitis (OR, 3.159),\n                      <jats:italic>Alternaria<\/jats:italic>\n                      sensitivity (OR, 10.37), and longer asthma duration (OR, 1.266). The best cut\u2010off values for detecting A. fumigatus positivity were 363.5\u2009IU\/mL for total IgE and 455 cells\/\u03bcL for absolute eosinophil count. In Af\u2010SA compared to Af\u2010UA, centrilobular nodules and peribronchial thickening were more common, and the bronchoarterial ratio was higher.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      sensitivity is a strong allergic stimulus in asthma, leading to laboratory, structural, clinical, and functional consequences. Af\u2010SA is a distinct asthma endotype independent of ABPA that is characterized by increased risk of severe clinical presentations and impaired lung function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14212","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T03:15:54Z","timestamp":1722827754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Aspergillus<\/i>\n                    \u2010sensitized asthma in children"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-0773","authenticated-orcid":false,"given":"Enes","family":"Celik","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy\u2010Immunology Akdeniz University School of Medicine  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-434X","authenticated-orcid":false,"given":"Dilara","family":"Kocacik\u00a0Uygun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy\u2010Immunology Akdeniz University School of Medicine  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2123-153X","authenticated-orcid":false,"given":"Mehmet Akif","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy\u2010Immunology Akdeniz University School of Medicine  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-981X","authenticated-orcid":false,"given":"Merve Sibel","family":"Gungoren","sequence":"additional","affiliation":[{"name":"Department of Immunoassay, Duzen Laboratories Group  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-8586","authenticated-orcid":false,"given":"Ayse","family":"Keven","sequence":"additional","affiliation":[{"name":"Department of Radiology Akdeniz University School of Medicine  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0886-3332","authenticated-orcid":false,"given":"Aysen","family":"Bingol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy\u2010Immunology Akdeniz University School of Medicine  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention.2021. 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