{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:05:12Z","timestamp":1784131512349,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["T001417N"],"award-info":[{"award-number":["T001417N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intense physical exercise in athletes increases the risk to develop exercise\u2010induced bronchocontriction (EIB). We aimed to study EIB prevalence and explore methods for effective EIB screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Three hundred twenty\u2010seven adolescent athletes (12\u201318\u2009years) performing at least 12\u2009h of sports a week were included. The evaluation consisted of spirometry, eucapnic voluntary hyperpnoea test (EVH) to evaluate for EIB, FeNO, skin prick testing, blood sampling (serum markers of epithelial damage and mast cell activation), and questionnaires (AQUA\n                      <jats:sup>\u00a9<\/jats:sup>\n                      , ACT, ACQ, and exposure and symptom\u2010related questions).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of all athletes, 22% tested positive for EIB (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972), 14% reported a previous asthma diagnosis and 40% were atopic. Eighty percent of EIB\n                      <jats:sup>+<\/jats:sup>\n                      athletes did not use any inhalation therapy. EIB\n                      <jats:sup>+<\/jats:sup>\n                      athletes were significantly younger, had decreased FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC (%), and increased post\u2010EVH\u2010reversibility (%) post\u2010salbutamol compared with EIB\n                      <jats:sup>\u2212<\/jats:sup>\n                      athletes. Furthermore, EIB was significantly associated with previous asthma diagnosis and atopy. The best predictors for a positive EVH test were AQUA\n                      <jats:sup>\u00a9<\/jats:sup>\n                      score\u2009\u2265\u20096 (sensitivity of 78%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0171) and wheezing during exercise (specificity of 82%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0002). FeNO negatively and significantly correlated with maximal fall in FEV\n                      <jats:sub>1<\/jats:sub>\n                      post\u2010EVH test in atopic athletes (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212.2735,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0056). Maximal fall in FEV\n                      <jats:sub>1<\/jats:sub>\n                      was also associated with prior PM\n                      <jats:sub>10<\/jats:sub>\n                      exposure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.036). Serum markers of epithelial damage were significantly associated with training type, training intensity, EIB severity, and prior air pollution exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support the effectiveness of a systematic respiratory screening approach, including baseline questionnaires, lung function tests, and FeNO measurement, to improve EIB detection in adolescent athletes in whom respiratory response to EVH testing is associated with prior exposure to air pollution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.14220","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T03:43:47Z","timestamp":1724125427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exercise\u2010induced bronchoconstriction in adolescent recreational athletes: Potential screening strategies"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-8886","authenticated-orcid":false,"given":"Janne","family":"Goossens","sequence":"first","affiliation":[{"name":"Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-4477","authenticated-orcid":false,"given":"Josefien","family":"Vandekerckhove","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation KU Leuven  Leuven Belgium"},{"name":"Clinical Division of Paediatrics UZ Leuven  Leuven 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