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The guidelines equally address food challenges in the research and the clinical settings. They first address the diagnostic tests which can guide the decision to conduct a challenge. Safety of food challenges is prime, and the various procedures and safety issues as well as medications potentially involved in challenges are extensively discussed. Challenges are suggested to be conducted with semi\u2010logarithmic incremental doses based on the protein content, typically for IgE\u2010mediated food allergy with intervals of 20\u201330\u2009min between doses. Specific protocols for other types of reactions such atopic dermatitis or gastrointestinal food allergy are detailed separately. Proper stopping criteria are essential in order to reduce the risk of false\u2010positive diagnoses, but also severe reactions. The guidelines recommend criteria based on \u201cgo on,\u201d \u201cstop,\u201d or \u201cobservation.\u201d These revised guidelines will clearly provide much needed guidance for food challenges in the research and clinical settings. 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