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However, the prediction of course of wheezing through childhood is difficult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether urinary EPX (a marker of eosinophil activation) in children at age 3\u2009years may be useful for the prediction of wheeze persistence and future asthma diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>U\u2010EPX was measured at age 3\u2009years (radioimmunoassay) in 906 participants in the population\u2010based birth cohort. Children attended follow\u2010ups to age 16\u2009years. We investigate the discriminative ability of u\u2010EPX and other factors in predicting asthma diagnosis at age 16 using receiver operating characteristic [ROC] curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 613 children with follow\u2010up information at age 16, 511 had data on u\u2010EPX at age 3 and asthma diagnosis at age 16\u2009years; of those; 133 (21.7%) had asthma. Based on longitudinal data, children were assigned to wheeze clusters: No wheeze (NWZ), early transient (ETW), late\u2010onset (LOW), intermittent (INT) and persistent wheeze (PEW). U\u2010EPX levels differed significantly between different wheeze clusters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003), with clusters characterised with persistent symptoms having higher u\u2010EPX. In the whole cohort, the best performing classification model for asthma diagnosis at age 16\u2009years included sex, u\u2010EPX, sensitisation and wheeze (area under the curve (AUC)\u2009=\u20090.82, 95% CI: 0.76\u20130.88). u\u2010EPX and allergic sensitisation alone had similar predictive power (AUC [95%CI]: 0.64 [0.58\u20130.71] and 0.65 [0.60\u20130.71]). The best performing classification model for asthma prediction among children with doctor\u2010confirmed wheeze in the first 3\u2009years included child's u\u2010EPX and sensitisation at age 3\u2009years, sex, gestational age and maternal atopy (AUC: 0.76, 95%CI: 0.67\u20130.85).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early\u2010life u\u2010EPX may be a useful non\u2010invasive marker for asthma prediction in adolescence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70013","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T08:24:46Z","timestamp":1733300686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of urinary eosinophilic protein X at age 3\u2009years and subsequent persistence of wheezing and asthma 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