{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:38:13Z","timestamp":1790401093627,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) predominantly manifests before age five, with significant phenotype variations across age groups. Despite increasing systemic treatments for pediatric AD, head\u2010to\u2010head comparisons in network meta\u2010analyses focused on children are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Through systematic searches of PubMed, Embase, Web of Science, and Cochrane Library up to March 2024, we identified randomized controlled trials (RCTs) evaluating systemic treatments for moderate\u2010to\u2010severe AD in children aged 2\u201318\u2009years. From 900 screened articles, 8 RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092636) met inclusion criteria, comparing dupilumab, baricitinib, upadacitinib, and abrocitinib versus placebo with standard care. Primary outcome was Eczema Area and Severity Index (EASI) scores at 12\u201316\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Upadacitinib demonstrated highest efficacy at both 30\u2009mg (risk difference [RD] 0.62 [0.53, 0.71]) and 15\u2009mg (RD 0.52 [0.42, 0.62]). Dupilumab (weight\u2010based dosing with corticosteroids; RD 0.43 [0.29, 0.57]), abrocitinib (200\u2009mg; RD 0.40 [0.29, 0.50]; 100\u2009mg; RD 0.30 [0.20, 0.41]), and baricitinib (4\u2009mg; RD 0.21 [0.06, 0.35]) also showed significant efficacy over placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis establishes a hierarchy of effectiveness among systemic therapies for pediatric AD, with upadacitinib showing highest efficacy. However, the predominance of adolescent data emphasizes the need for age\u2010stratified studies in younger children and long\u2010term safety assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70045","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:19:53Z","timestamp":1739344793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparative efficacy of biologics and small molecule drugs in\u00a0treating pediatric atopic dermatitis in patients aged 2\u201318\u2009years: A 12\u201316\u2009week network meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"36","author":[{"given":"Su\u2010Boon","family":"Yong","sequence":"first","affiliation":[{"name":"Department of Allergy, Immunology and Rheumatology China Medical University Children's Hospital  Taichung 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