{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:05:21Z","timestamp":1789783521727,"version":"4.0.1"},"reference-count":124,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"Abstract<\/jats:title>\n \n Component\u2010resolved diagnostics (CRD) have revolutionized allergy diagnosis, offering enhanced accuracy and insights into allergen sensitization patterns. This review explores geographical variances in CRD for food and aeroallergens across the Asia\u2010Pacific region. We examine the varying prevalence of allergic diseases and the utility of CRD in diagnosing common food allergies, including peanut, shellfish, fish, wheat, and fruits. Notable differences in serum\u2010specific (sp)IgE sensitization patterns and the clinical relevance of particular allergen components are observed between populations in Asian countries and those in Europe and the United States. For food allergies, the literature reports significant differences in allergen components and their diagnostic utility across various countries. Peanut allergy diagnostics, particularly Ara h 2 spIgE, show varying sensitivity and specificity between Asian and Western populations. In shellfish allergy, emerging allergens beyond tropomyosin are gaining importance in the Asia\u2010Pacific region. Fish and wheat allergies also demonstrate unique sensitization patterns, emphasizing the need for region\u2010specific diagnostic approaches. Regarding aeroallergens, pollen sensitization profiles vary widely across the region, influenced by local flora and climate, to influence symptoms of pollen food allergy syndrome. House dust mite allergens remain a significant concern, with high sensitization rates to major components like Der p 1, Der p 2, and the emerging Der p 23. The cross\u2010reactivity between house dust mite and shellfish allergens is particularly relevant in this region. These findings emphasize the need for region\u2010specific CRD approaches, considering local allergen profiles and sensitization patterns. As the prevalence of allergic diseases continues to rise in the Asia\u2010Pacific, further research into locally relevant allergens and their components is crucial for improving diagnosis, patient management, and targeted immunotherapy strategies in this diverse region.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>","DOI":"10.1111\/pai.70054","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:44:41Z","timestamp":1742373881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploring geographical variances in component\u2010resolved diagnosis within the Asia\u2010Pacific region"],"prefix":"10.1111","volume":"36","author":[{"given":"Carmen","family":"Riggioni","sequence":"first","affiliation":[{"name":"Division of Immunology and Allergy The Hospital for Sick Children and the SickKids Food Allergy and Anaphylaxis Program Toronto Ontario Canada"},{"name":"Department of Paediatrics Temerty Faculty of Medicine, University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-4478","authenticated-orcid":false,"given":"Agnes Sze\u2010Yin","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin Hong Kong China"},{"name":"Hong Kong Hub of Paediatric Excellence (HOPE), The Chinese University of Hong Kong Hong kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Yee\u2010Yan","family":"Wai","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin Hong Kong China"},{"name":"Hong Kong Hub of Paediatric Excellence (HOPE), The Chinese University of Hong Kong Hong kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Davies","sequence":"additional","affiliation":[{"name":"Population Allergy Group, Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Centre for Immunology and Infection Control, Queensland University of Technology Brisbane Queensland Australia"},{"name":"National Allergy Centre of Excellence, Murdoch Children's Research Institute Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mongkhon","family":"Sompornrattanaphan","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-2057","authenticated-orcid":false,"given":"Punchama","family":"Pacharn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Siriraj Hospital, Mahidol University Salaya Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Chamani","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0558-153X","authenticated-orcid":false,"given":"Tim","family":"Brettig","sequence":"additional","affiliation":[{"name":"Population Allergy Group, Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-6628","authenticated-orcid":false,"given":"Rachel L.","family":"Peters","sequence":"additional","affiliation":[{"name":"Population Allergy Group, Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1111\/pai.13705","article-title":"Ana o 3 sIgE testing increases the accuracy of cashew allergy diagnosis using a two\u2010step model","volume":"33","author":"Dang TD","year":"2022","journal-title":"Pediatr Allergy Immunol"},{"issue":"4","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.jaci.2012.01.056","article-title":"Increasing the 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