{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:08:44Z","timestamp":1787843324588,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Since the early introduction of peanut to prevent IgE\u2010mediated peanut allergy, other case series have suggested an increased incidence of peanut\u2010triggered Food Protein Induced Enterocolitis Syndrome (FPIES). Data on the prevalence of peanut\u2010induced FPIES in prospective cohorts are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The PeanutNL cohort is a prospective cohort that included infants at risk of peanut allergy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009706) as well as infants with reactions to peanut at home after early introduction (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009186). They all introduced peanut before the age of 12\u2009months. Oral food challenges were performed to introduce peanut or to evaluate reactions to peanut at home.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 706 infants that were included for first introduction of peanut, 2 had reactions with a phenotype compatible with FPIES (0.3%). Of the 186 infants with reactions to peanut at home, 6 were diagnosed with FPIES (3.2%). Seven out of 8 cases had ingestions of peanut without reactions at home or during clinical introduction before FPIES became apparent. During a 3\u2010year follow\u2010up, six infants (75%) were shown to be tolerant to peanut before the age of 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of challenge\u2010proven peanut\u2010induced FPIES in a Dutch cohort of atopic infants that introduced peanut between the ages of 4 and 11\u2009months is 0.3%. The majority of cases were tolerant to peanut before the age of 3\u2009years. When introducing peanut in the first year of life, physicians should be aware of FPIES reactions, but it should not be a reason to avoid early introduction of peanut.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70058","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T03:23:51Z","timestamp":1741836231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The prevalence of peanut\u2010triggered food protein\u2010induced enterocolitis syndrome in a prospective cohort of infants introducing peanut in the first year of life"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3599-6888","authenticated-orcid":false,"given":"Dirk H. J.","family":"Verhoeven","sequence":"first","affiliation":[{"name":"Department of Pediatrics Reinier de Graaf Hospital  Delft The Netherlands"},{"name":"Section of Allergology and Clinical Immunology, Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geertje","family":"Hofstra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Martini Hospital  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Faber","sequence":"additional","affiliation":[{"name":"Pediatrics Allergy Treatment Centre Deventer Hospital  Deventer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Benjamin\u2010van","family":"Aalst","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Northwest Clinics  Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijke","family":"Breukels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Elkerliek Hospital  Helmond The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy Gerth","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Section of Allergology and Clinical Immunology, Department of Internal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Reinier de Graaf Hospital  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.038"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.12.023"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.02.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/jfa.2021.3.210003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.10.043"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.10.023"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.966"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.06.032"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.045"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1105"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13983"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.08.047"},{"key":"e_1_2_12_15_1","first-page":"157","article-title":"Preventing food allergy: avoid avoidance","volume":"17","author":"Klok T","year":"2017","journal-title":"Ned Tijdschr Allergie Klin Immunol"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_12_17_1","unstructured":"KoffemanE Van ThuijlA KokI.Food protein induced enterocolitis syndome (FPIES) in children. Guideline for pediatricians. Dutch society for pediatrics.2020https:\/\/www.nvk.nl\/themas\/kwaliteit\/richtlijnen\/richtlijn?componentid=18219008. Accessed September 16 2024"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.10.047"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2022.14.6.587"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.04.008"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T16:52:49Z","timestamp":1742921569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/pai.70058"],"URL":"https:\/\/doi.org\/10.1111\/pai.70058","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.70058\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70058\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70058"}}